PMID- 33409975
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20220514
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 31
IP  - 4
DP  - 2021 Apr
TI  - Improvement of Postprandial Lipid Metabolism After Ileal Transposition in 
      Non-obese Diabetic Rats.
PG  - 1572-1578
LID - 10.1007/s11695-020-05158-z [doi]
AB  - BACKGROUND: Ileal transposition (IT) could reduce obesity and improve type 2 
      diabetes mellitus (T2DM). The main aim of our study was to investigate lipid 
      metabolism changes in T2DM rats after IT without a weight reduction effect. 
      METHODS: Thirty male diabetic rats were randomly divided into IT, sham IT (SI), 
      and control groups. The levels of plasma cholesterol, high-density lipoprotein 
      (HDL), low-density lipoprotein (LDL), triglycerides (TGs), and bile acid were 
      measured. After sacrifice, the white adipose tissue, brown adipose tissue and 
      liver were weighed. RESULTS: IT induced significant improvement in glucose and 
      lipid metabolism. There were no significant differences in the levels of 
      cholesterol (P = 0.87), HDL (P = 0.70), LDL (P = 0.96), or TGs (P = 0.97) among 
      the groups before surgery. After IT, the levels of cholesterol (P = 0.019), LDL 
      (P = 0.004), and TGs (P < 0.001) were lower than those in the SI and control 
      groups, while the level of HDL was not significantly different compared to those 
      of the other groups (P = 0.437). Higher bile acid level (P = 0.001), lower white 
      adipose tissue/total body weight ratio (P < 0.001), and lower liver/total body 
      weight ratio (P = 0.003) were found in the IT group. The BAT/total body weight 
      ratio in the IT group was higher than that in the SI or control groups 
      (P = 0.002). CONCLUSIONS: IT could improve lipid metabolism in diabetic rats.
FAU - Chen, Weijie
AU  - Chen W
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China.
FAU - Yin, Haixin
AU  - Yin H
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China.
FAU - Qu, Qiang
AU  - Qu Q
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China.
FAU - Xiao, Jianchun
AU  - Xiao J
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China.
FAU - Gong, Fengying
AU  - Gong F
AD  - Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of 
      Health, Peking Union Medical College Hospital, Chinese Academy of Medical 
      Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic of China.
FAU - He, Xiaodong
AU  - He X
AUID- ORCID: 0000-0002-6682-2926
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic 
      of China. hxdpumch@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210106
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Experimental
MH  - *Diabetes Mellitus, Type 2
MH  - Lipid Metabolism
MH  - Male
MH  - Obesity
MH  - *Obesity, Morbid/surgery
MH  - Rats
MH  - Triglycerides
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Bile acid
OT  - Ileal transposition
OT  - Type 2 diabetes mellitus
EDAT- 2021/01/08 06:00
MHDA- 2021/04/20 06:00
CRDT- 2021/01/07 06:13
PHST- 2020/08/28 00:00 [received]
PHST- 2020/12/07 00:00 [accepted]
PHST- 2020/12/03 00:00 [revised]
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2021/01/07 06:13 [entrez]
AID - 10.1007/s11695-020-05158-z [pii]
AID - 10.1007/s11695-020-05158-z [doi]
PST - ppublish
SO  - Obes Surg. 2021 Apr;31(4):1572-1578. doi: 10.1007/s11695-020-05158-z. Epub 2021 
      Jan 6.