PMID- 33410266
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 47
IP  - 3
DP  - 2021 Mar
TI  - Effects of androgenic properties of progestin combined with ethinyl estradiol on 
      vascular endothelial reactivity, plasma lipids and free radical production in 
      women with endometriosis.
PG  - 941-948
LID - 10.1111/jog.14620 [doi]
AB  - AIM: Endothelial reactivity is inhibited and oxidative stress is enhanced in 
      women with endometriosis. Testosterone may adversely affect lipids and 
      endothelium. We investigated the effects of androgenic properties of progestins 
      combined with ethinyl estradiol (EE) on endothelial function, lipids and free 
      radical production in such women. METHODS: Women with endometriosis were treated 
      with 20 mug EE + 3 mg drospirenone (DRSP) or 35 mug EE + 1 mg norethisterone (NET) 
      for 3 months. Plasma concentrations of sex hormone-binding globulin (SHBG), 
      lipids, copper (Cu), derivatives of reactive oxygen metabolites (d-ROMs), 
      biological antioxidant potential (BAP), nitrite/nitrate, endothelin-1 and 
      asymmetrical dimethylarginine (ADMA) were measured before and after treatment. 
      Flow-mediated vasodilation (FMD) of the brachial artery was measured by 
      ultrasonography. RESULTS: DRSP group, but not NET group, significantly increased 
      FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while 
      decreased endothelin-1 concentrations. In both groups, ADMA and LDL cholesterol 
      concentrations were significantly decreased, but triglyceride, SHBG, d-ROMs, Cu 
      and ceruloplasmin concentrations increased, and BAP concentrations did not 
      change. DRSP group significantly increased HDL cholesterol concentrations, 
      whereas NET group decreased its concentrations. Changes in triglyceride 
      correlated positively either with changes in SHBG (r = 0.57, P < 0.001) or with 
      small dense LDL cholesterol (r = 0.45, P = 0.005). Changes in Cu correlated 
      positively with changes in d-ROMs (r = 0.87, P < 0.001). CONCLUSION: Androgenic 
      properties of progestin may counteract EE's favorable effects on endothelial 
      function and HDL cholesterol, while eliminating its adverse effects on increased 
      triglyceride-induced small dense LDL cholesterol in women with endometriosis.
CI  - (c) 2021 Japan Society of Obstetrics and Gynecology.
FAU - Sakurada, Takahiro
AU  - Sakurada T
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Nagakute, Aichi, Japan.
FAU - Matsushita, Hiroshi
AU  - Matsushita H
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Nagakute, Aichi, Japan.
FAU - Noguchi, Yasuyuki
AU  - Noguchi Y
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Nagakute, Aichi, Japan.
FAU - Shinohara, Koichi
AU  - Shinohara K
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Nagakute, Aichi, Japan.
FAU - Watanabe, Kazushi
AU  - Watanabe K
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Nagakute, Aichi, Japan.
FAU - Wakatsuki, Akihiko
AU  - Wakatsuki A
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Nagakute, Aichi, Japan.
LA  - eng
GR  - 17K11302/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20210106
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Androgens)
RN  - 0 (Contraceptives, Oral, Combined)
RN  - 0 (Free Radicals)
RN  - 0 (Lipids)
RN  - 0 (Progestins)
RN  - 423D2T571U (Ethinyl Estradiol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Androgens
MH  - Cholesterol
MH  - Contraceptives, Oral, Combined/adverse effects
MH  - *Endometriosis/drug therapy
MH  - Endothelium
MH  - Ethinyl Estradiol
MH  - Female
MH  - Free Radicals
MH  - Humans
MH  - Lipids
MH  - *Progestins
OTO - NOTNLM
OT  - HDL cholesterol
OT  - endometriosis
OT  - free radical
OT  - small dense LDL cholesterol
OT  - vascular function
EDAT- 2021/01/08 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/01/07 06:17
PHST- 2020/07/29 00:00 [received]
PHST- 2020/11/10 00:00 [revised]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/07 06:17 [entrez]
AID - 10.1111/jog.14620 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2021 Mar;47(3):941-948. doi: 10.1111/jog.14620. Epub 2021 
      Jan 6.