PMID- 33411139
OWN - NLM
STAT- MEDLINE
DCOM- 20210518
LR  - 20210518
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 40
IP  - 6
DP  - 2021 Jun
TI  - Reproducibility of minor salivary gland biopsy reports in Sjogren's syndrome and 
      its correlation with disease biomarkers.
PG  - 2285-2292
LID - 10.1007/s10067-020-05532-3 [doi]
AB  - INTRODUCTION/OBJECTIVE: Sjogren's syndrome (SS) is a systemic autoimmune disease 
      that is challenging to diagnose. Although minor salivary gland biopsy (MSGB) is a 
      useful ancillary study, different factors make its interpretation difficult. 
      Also, the significance of distinct histopathological findings is unknown. We 
      aimed to determine the concordance between pathologists and rheumatologists in 
      interpreting the MSGB results, as well as the correlation between MSGB findings, 
      paraclinical features, and SS diagnosis. METHODS: This descriptive retrospective 
      study reviewed medical charts from 998 individuals from a single center where 
      MSGBs had been performed. Rheumatologists interpreted biopsy reports from 
      pathologists, and interobserver variability was calculated. Logistic regression 
      using immunological parameters and histological findings was performed. RESULTS: 
      We included 998 patients with a median age of 55 years (45-64 years); the 
      majority of patients were females (n = 934, 93.6%). Chisholm and Mason's scoring 
      system was the most frequently used scale (55.1%). There was a good correlation 
      between pathologists and rheumatologists for diagnosing SS using MSGB findings 
      (Cohen's kappa 0.91). We observed a strong association between interstitial 
      plasmocytes and SS (OR 24, 95% CI 9.09-64.94, p = 0). CONCLUSION: The MSGB is an 
      essential tool for the diagnosis of SS. Although different factors may negatively 
      affect its reproducibility, histological findings, such as interstitial 
      plasmocytes, may predict the risk of developing SS. Key Points * We provide 
      information based on 998 patients with suspected SS diagnosis. * Chisholm and 
      Mason's scale is the most frequently used compared to Greenspan's and Tarpley's 
      scales. * There is good correlation between pathologists and rheumatologists for 
      the diagnosis of SS using MSGB.
FAU - Vivas, Alvaro J
AU  - Vivas AJ
AD  - GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina 
      Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cra 98 Nro.18-49, 
      Cali, 760032, Colombia.
AD  - Medical School, Universidad Icesi, Calle 18 No. 122-135, Cali, Colombia.
FAU - Bautista-Vargas, Mario
AU  - Bautista-Vargas M
AD  - GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina 
      Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cra 98 Nro.18-49, 
      Cali, 760032, Colombia.
AD  - Unit of Rheumatology, Medical School, Universidad Icesi, Calle 18 No. 122-135, 
      Cali, Colombia.
FAU - Portacio, Sebastian
AU  - Portacio S
AD  - Medical School, Universidad Icesi, Calle 18 No. 122-135, Cali, Colombia.
FAU - Garces-Palacio, Andres
AU  - Garces-Palacio A
AD  - Medical School, Universidad Icesi, Calle 18 No. 122-135, Cali, Colombia.
FAU - Urbano, Maria-Alejandra
AU  - Urbano MA
AD  - Medical School, Universidad Icesi, Calle 18 No. 122-135, Cali, Colombia.
FAU - Agualimpia, Andres
AU  - Agualimpia A
AD  - GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina 
      Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cra 98 Nro.18-49, 
      Cali, 760032, Colombia.
AD  - Unit of Rheumatology, Fundacion Valle del Lili, Cra 98 No. 18-49, Cali, 760032, 
      Colombia.
FAU - Ruiz-Ordonez, Ingrid
AU  - Ruiz-Ordonez I
AD  - GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina 
      Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cra 98 Nro.18-49, 
      Cali, 760032, Colombia.
AD  - Fundacion Valle del Lili, Centro de Investigaciones Clinicas, Cra 98 No. 18-49, 
      Cali, 760032, Colombia.
FAU - Nieto-Aristizabal, Ivana
AU  - Nieto-Aristizabal I
AD  - GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina 
      Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cra 98 Nro.18-49, 
      Cali, 760032, Colombia.
AD  - Fundacion Valle del Lili, Centro de Investigaciones Clinicas, Cra 98 No. 18-49, 
      Cali, 760032, Colombia.
FAU - Tobon, Gabriel J
AU  - Tobon GJ
AUID- ORCID: 0000-0002-6031-4218
AD  - GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina 
      Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cra 98 Nro.18-49, 
      Cali, 760032, Colombia. gjtobon@icesi.edu.co.
AD  - Unit of Rheumatology, Fundacion Valle del Lili, Cra 98 No. 18-49, Cali, 760032, 
      Colombia. gjtobon@icesi.edu.co.
LA  - eng
PT  - Journal Article
DEP - 20210107
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - *Salivary Glands, Minor
MH  - *Sjogren's Syndrome/diagnosis
OTO - NOTNLM
OT  - Chisholm and Mason
OT  - Minor salivary gland biopsy
OT  - Reproducibility
OT  - Sjogren's syndrome
EDAT- 2021/01/08 06:00
MHDA- 2021/05/19 06:00
CRDT- 2021/01/07 12:17
PHST- 2020/09/02 00:00 [received]
PHST- 2020/12/01 00:00 [accepted]
PHST- 2020/11/17 00:00 [revised]
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/05/19 06:00 [medline]
PHST- 2021/01/07 12:17 [entrez]
AID - 10.1007/s10067-020-05532-3 [pii]
AID - 10.1007/s10067-020-05532-3 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2021 Jun;40(6):2285-2292. doi: 10.1007/s10067-020-05532-3. Epub 
      2021 Jan 7.