PMID- 33411500
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1948-7193 (Electronic)
IS  - 1948-7193 (Linking)
VI  - 12
IP  - 2
DP  - 2021 Jan 20
TI  - Maternal Exposure to Di-(2-ethylhexyl) Phthalate Impairs Hippocampal Synaptic 
      Plasticity in Male Offspring: Involvement of Damage to Dendritic Spine 
      Development.
PG  - 311-322
LID - 10.1021/acschemneuro.0c00612 [doi]
AB  - Exposure to di-(2-ethylhexyl) phthalate (DEHP), a widely used kind of 
      plasticizer, can result in neurodevelopment impairments and learning and memory 
      disorders. We studied the effects and possible mechanisms of maternal DEHP 
      treatment on hippocampal synaptic plasticity in offspring. Pregnant Wistar rats 
      were randomly divided into four groups and received 0, 30, 300, 750 (mg/kg)/d 
      DEHP by gavage from gestational day (GD) 0 to postnatal day (PN) 21. Our data 
      showed that DEHP exposure impaired hippocampal synaptic plasticity, damaged 
      synaptic ultrastructure, and decreased synaptic protein levels in male pups. 
      Furthermore, DEHP decreased the density of dendritic spines, affected F-actin 
      polymerization, and downregulated the Rac1/PAK/LIMK1/cofilin signaling pathway in 
      male offspring. However, the alterations in the hippocampi of female offspring 
      were not observed. These results illustrate that maternal DEHP exposure could 
      impair hippocampal synaptic plasticity by affecting synaptic structure and 
      dendritic spine development in male offspring, which may be attributed to altered 
      cytoskeleton construction induced by downregulation of the Rac1/PAK/LIMK1/cofilin 
      signaling pathway.
FAU - Dong, Jing
AU  - Dong J
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Fu, Hui
AU  - Fu H
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Fu, Yuanyuan
AU  - Fu Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - You, Mingdan
AU  - You M
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Li, Xudong
AU  - Li X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Wang, Chaonan
AU  - Wang C
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Leng, Kunkun
AU  - Leng K
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
FAU - Chen, Jie
AU  - Chen J
AUID- ORCID: 0000-0002-5183-4852
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenyang 110122, Peoples' Republic of 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210107
PL  - United States
TA  - ACS Chem Neurosci
JT  - ACS chemical neuroscience
JID - 101525337
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Dendritic Spines
MH  - *Diethylhexyl Phthalate/toxicity
MH  - Female
MH  - Hippocampus
MH  - Humans
MH  - Male
MH  - Maternal Exposure
MH  - Neuronal Plasticity
MH  - Phthalic Acids
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - DEHP
OT  - dendritic spine
OT  - hippocampus
OT  - synapse
OT  - synaptic plasticity
EDAT- 2021/01/08 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/01/07 17:12
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/07 17:12 [entrez]
AID - 10.1021/acschemneuro.0c00612 [doi]
PST - ppublish
SO  - ACS Chem Neurosci. 2021 Jan 20;12(2):311-322. doi: 10.1021/acschemneuro.0c00612. 
      Epub 2021 Jan 7.