PMID- 33413319
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20240330
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jan 7
TI  - The relationship between red blood cell distribution and islet beta-cell function 
      indexes in patients with type 2 diabetes.
PG  - 7
LID - 10.1186/s12902-020-00668-4 [doi]
LID - 7
AB  - BACKGROUND: Red cell distribution width (RDW) is a predicter of infections, 
      cancer and diabetes. However, the relationship between RDW and beta-cell function 
      and insulin resistance remains unclear in patients with type 2 diabetes mellitus 
      (T2DM). The aim of the study was to explore the relationship between RDW and 
      beta-cell function in patients with T2DM. METHODS: A total of 559 T2DM patients were 
      enrolled in this cross-sectional study. Patients were divided into three groups 
      according to RDW tertiles. Clinical and biochemical characteristics such as age, 
      duration of diabetes, blood pressure, RDW, glycosylated hemoglobin A1c (HbA1c), 
      C-peptide and lipid profiles were collected. Homeostasis model assessment of 
      insulin resistance (HOMA2IR) and homeostasis model assessment of beta-cell function 
      (HOMA2%B) were assessed using homeostasis model assessment (HOMA) based on 
      fasting blood glucose (FBG) and fasting C-peptide index (FCPI). Correlations and 
      multiple linear regressions were performed to explore the association between RDW 
      and islet function indexes in total population and in different gender subgroups. 
      RESULTS: The HOMA2%B gradually increased according to RDW tertiles (lowest, 
      second, highest RDW tertiles; 47.1(32.9-75.4), 54.05(34.1-81), and 
      57.9(38.65-95.4), respectively; P = 0.036). Correlation analysis indicated that 
      there were significant correlations between RDW and age, diabetes duration, 
      diastolic blood pressure (DBP), triglycerides (TG), aspartate transaminase (AST), 
      FBG, HbA1c and HOMA2%B in all subjects. In male subjects, RDW correlated 
      positively with age, high-density lipoprotein cholesterol (HDL) and AST, and it 
      correlated negatively with body mass index (BMI), DBP and TG. In female subjects, 
      RDW correlated positively with age, duration, serum creatinine (Cr), FCPI and 
      HOMA2%B, and it correlated negatively with alanine transaminase (ALT), FBG and 
      HbA1c. Multiple linear regressions indicated that RDW was significantly 
      correlated with HOMA2%B and HbA1c in the total population in both unadjusted and 
      adjusted analysis. This finding could be reproduced in the subgroup of men for 
      HOMA2%B only and in women for HbA1c only. CONCLUSIONS: RDW is associated with 
      beta-cell function assessed by HOMA2%B after adjusting for covariates in male T2DM 
      patients.
FAU - Zhang, Deyuan
AU  - Zhang D
AD  - Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, People's Republic of China.
FAU - Zhang, Siqi
AU  - Zhang S
AD  - Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, People's Republic of China.
FAU - Wang, Lifang
AU  - Wang L
AD  - Clinical Epidemiology Research Center, Beijing Jishuitan Hospital, Beijing, 
      People's Republic of China.
FAU - Pan, Tianrong
AU  - Pan T
AD  - Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, People's Republic of China. 
      pantianrong1968@163.com.
FAU - Zhong, Xing
AU  - Zhong X
AD  - Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui Province, People's Republic of China. 
      zhongxing761@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210107
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Blood Glucose/analysis
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/metabolism/pathology
MH  - Erythrocytes/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - *Insulin Resistance
MH  - Insulin-Secreting Cells/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
PMC - PMC7791877
OTO - NOTNLM
OT  - Glycosylated hemoglobin A1c
OT  - Red blood cell distribution width
OT  - Type 2 diabetes mellitus
OT  - beta-Cell function
COIS- The authors declare that they have no competing interests.
EDAT- 2021/01/09 06:00
MHDA- 2021/10/05 06:00
PMCR- 2021/01/07
CRDT- 2021/01/08 05:43
PHST- 2020/03/17 00:00 [received]
PHST- 2020/12/16 00:00 [accepted]
PHST- 2021/01/08 05:43 [entrez]
PHST- 2021/01/09 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/01/07 00:00 [pmc-release]
AID - 10.1186/s12902-020-00668-4 [pii]
AID - 668 [pii]
AID - 10.1186/s12902-020-00668-4 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2021 Jan 7;21(1):7. doi: 10.1186/s12902-020-00668-4.