PMID- 33413696
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20240226
IS  - 2050-6511 (Electronic)
IS  - 2050-6511 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Jan 7
TI  - N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen 
      on the rat hot plate test.
PG  - 4
LID - 10.1186/s40360-020-00469-4 [doi]
LID - 4
AB  - BACKGROUND: Acetaminophen (APAP) induced hepatotoxicity is a clinically important 
      problem. Up to now, interventive therapy with n-acetylcysteine (NAC) has been 
      considered as a gold-standard treatment for APAP overdose. However, no study has 
      focused on the efficacy of these drugs' concurrent administration on probable 
      enhancing therapeutic outcomes. Thus, this study was aimed to investigate the 
      analgesic effect of co-administration of NAC and acetaminophen in male rats. The 
      NAC-APAP drug formulation may demonstrate the stranger antinociceptive effect. 
      METHODS: Forty-eight male Sprague-Dawley rats (12-14 weeks) randomly divided into 
      six equal groups; control, APAP (received 300 mg/kg APAP), NAC (received 
      600 mg/kg NAC) and APAP+ NAC groups that received simultaneously 300 mg/kg APAP 
      with 200-600 mg/kg NAC (AN200, AN400, AN600). All administrations were done 
      orally for once. The antinociceptive effect was recorded by measurement of 
      latency period on a hot plate in 30, 60, and 90 min after administrations. 
      RESULTS: The results showed that NAC's concurrent administration with APAP, 
      dose-dependently increased APAP analgesic effects (p< 0.0001). Moreover, NAC 
      treatment exhibited an antinociceptive effect in 60 and 90 min, per se. The 
      treatments had no adverse effect on liver enzymes and oxidative stress. 
      CONCLUSION: Co-administration of NAC with APAP can improve the antinociceptive 
      effect of APAP. It is suggested that this compound can enhance analgesic effects 
      of APAP and eventually lead to a reduction in acetaminophen dose. Further studies 
      are needed to evaluate the molecular mechanism of this hyper analgesic effect.
FAU - Nakhaee, Samaneh
AU  - Nakhaee S
AD  - Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of 
      Medical Sciences (BUMS), Birjand, Iran.
FAU - Dastjerdi, Mohammad
AU  - Dastjerdi M
AD  - Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, 
      Iran.
FAU - Roumi, Hesam
AU  - Roumi H
AD  - Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, 
      Iran.
FAU - Mehrpour, Omid
AU  - Mehrpour O
AD  - Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of 
      Medical Sciences (BUMS), Birjand, Iran.
AD  - Mel and Enid Zuckerman, College of Public Health, University of Arizona, Tucson, 
      Arizona, USA.
FAU - Farrokhfall, Khadijeh
AU  - Farrokhfall K
AD  - Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, 
      Iran. kfarrokhfall@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210107
PL  - England
TA  - BMC Pharmacol Toxicol
JT  - BMC pharmacology & toxicology
JID - 101590449
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 362O9ITL9D (Acetaminophen)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetaminophen/*administration & dosage
MH  - Acetylcysteine/*administration & dosage
MH  - Analgesics, Non-Narcotic/*administration & dosage
MH  - Animals
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Hot Temperature/adverse effects
MH  - Male
MH  - Pain/*drug therapy
MH  - Rats, Sprague-Dawley
MH  - Rats
PMC - PMC7791802
OTO - NOTNLM
OT  - Acetaminophen
OT  - Analgesic effect
OT  - Co-administration
OT  - Hot plate
OT  - N-acetyl cysteine
OT  - Pain
OT  - Rat
COIS- There is no conflict of interest.
EDAT- 2021/01/09 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/01/07
CRDT- 2021/01/08 05:48
PHST- 2020/08/11 00:00 [received]
PHST- 2020/12/22 00:00 [accepted]
PHST- 2021/01/08 05:48 [entrez]
PHST- 2021/01/09 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/01/07 00:00 [pmc-release]
AID - 10.1186/s40360-020-00469-4 [pii]
AID - 469 [pii]
AID - 10.1186/s40360-020-00469-4 [doi]
PST - epublish
SO  - BMC Pharmacol Toxicol. 2021 Jan 7;22(1):4. doi: 10.1186/s40360-020-00469-4.