PMID- 33414119
OWN - NLM
STAT- MEDLINE
DCOM- 20210224
LR  - 20230108
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 14
IP  - 1
DP  - 2021 Jan 7
TI  - Acute oesophageal necrosis in multiple endocrine neoplasia type 1: an undescribed 
      complication.
LID - 10.1136/bcr-2020-238214 [doi]
LID - e238214
AB  - Acute oesophageal necrosis (AEN) is a rare entity that most commonly presents as 
      upper gastrointestinal bleeding. Complex pathophysiology may include oesophageal 
      ischaemia as well as reflux of acidic gastric contents causing oesophageal 
      mucosal injury. Management is supportive and directed at underlying comorbidities 
      however prognosis is poor with complications such as oesophageal perforation, 
      stricture and stenosis. Here we present the case of a 56-year-old man with 
      multiple endocrine neoplasia type 1 (MEN1) and gastro-oesophageal reflux disease 
      who developed AEN as a result of undiagnosed Zollinger-Ellison syndrome (ZES), 
      duodenal ulcer-induced obstruction and hypotension from new-onset atrial 
      fibrillation. AEN as the presentation of MEN1-associated ZES is an unusual 
      presentation of this disease which clinicians, particularly endocrinologists and 
      endoscopists, should be aware of.
CI  - (c) BMJ Publishing Group Limited 2020. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Bhattacharya, Sumona
AU  - Bhattacharya S
AUID- ORCID: 0000-0002-8664-3423
AD  - Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney 
      Diseases, National Institutes of Health, Bethesda, Maryland, USA 
      sumona.bhattacharya@nih.gov.
FAU - Blau, Jenny E
AU  - Blau JE
AD  - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
FAU - Koh, Christopher
AU  - Koh C
AD  - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney 
      Diseases, National Institutes of Health, Bethesda, Maryland, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210107
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
SB  - IM
MH  - Esophageal Diseases/*pathology
MH  - Gastroesophageal Reflux/complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications/diagnosis
MH  - Necrosis
MH  - Zollinger-Ellison Syndrome/*complications
PMC - PMC7797279
OTO - NOTNLM
OT  - gastro-oesophageal reflux
OT  - gastroenterology
OT  - metabolic disorders
OT  - ulcer
COIS- Competing interests: None declared.
EDAT- 2021/01/09 06:00
MHDA- 2021/02/25 06:00
PMCR- 2023/01/07
CRDT- 2021/01/08 05:59
PHST- 2021/01/08 05:59 [entrez]
PHST- 2021/01/09 06:00 [pubmed]
PHST- 2021/02/25 06:00 [medline]
PHST- 2023/01/07 00:00 [pmc-release]
AID - 14/1/e238214 [pii]
AID - bcr-2020-238214 [pii]
AID - 10.1136/bcr-2020-238214 [doi]
PST - epublish
SO  - BMJ Case Rep. 2021 Jan 7;14(1):e238214. doi: 10.1136/bcr-2020-238214.