PMID- 33415463
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210810
LR  - 20210810
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 188
IP  - 2
DP  - 2021 Jan 7
TI  - Solvent-loaded metal-organic framework of type MIL-101(Cr)-NH(2) for the 
      dispersive solid-phase extraction and UHPLC-MS/MS analysis of herbicides from 
      paddy field waters.
PG  - 30
LID - 10.1007/s00604-020-04661-5 [doi]
AB  - A novel solvent-loaded dispersive solid-phase extraction (SL-DSPE) method 
      integrated with liquid-phase microextraction (LPME) has been developed by the 
      direct loading of solvent into the pores of a metal-organic framework (MOF), 
      MIL-101(Cr)-NH(2). Despite numerous advantages of MOFs, they are usually highly 
      hydrophobic which limits their dispersibility and therefore effective contact 
      with the analytes in aqueous samples. To overcome this and promote its 
      interactions with polar compounds, MIL-101(Cr) was functionalized with -NH(2) and 
      loaded with a comparatively polar organic solvent, dichloromethane. The purpose 
      of dichloromethane was to condition the MIL-101(Cr)-NH(2), promote LPME of the 
      analytes and facilitate the re-collection of the materials after the extraction. 
      Five chlorophenoxy acid herbicides, including 2,4-dichlorophenoxyacetic acid, 
      2,4,5-trichlorophenoxyacetic acid, 4-chlorophenoxyacetic acid, 
      2-(2,4-dichlorophenoxy)propionic acid, and 2-(2,4,5-trichlorophenoxy)propionic 
      acid, were studied and determined by ultra-high-performance liquid 
      chromatography-tandem mass spectrometry (UHPLC-MS/MS). MIL-101(Cr)-NH(2) was 
      characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, 
      scanning electron microscopy, and surface area measurement. Several extraction 
      parameters were optimized, and under the most favorable conditions, the 
      SL-DSPE-UHPLC-MS/MS method achieved enrichment factors between 25 and 66. Low 
      limits of detection (2.66-19.7 ng.L(-1)) and wide dynamic working ranges with 
      good linearity (r(2) >/= 0.991) were attained for all analytes. The method was 
      repeatable, with intra- and inter-day relative standard deviations (RSDs) 
      below 4.5 and 7.6%, respectively, for three replicate determinations. The 
      application of SL-DSPE-UHPLC-MS/MS to paddy field waters gave satisfactory 
      relative recoveries ranging between 80.2 and 108%, with RSDs better 8.4%. Several 
      of the CPAs were detected in these samples. Graphical abstract Schematic of the 
      solvent-loaded dispersive solid-phase extraction procedure. By directly loading 
      dichloromethane into the pores of MIL-101(Cr)-NH(2), this method improves the 
      extraction capability of the sorbent through the combination of solvent- and 
      sorbent-based microextraction.
FAU - Tan, Sze Chieh
AU  - Tan SC
AUID- ORCID: 0000-0003-0791-0982
AD  - NUS Graduate School for Integrative Sciences and Engineering, National University 
      of Singapore, University Hall, Tan Chin Tuan Wing #04-02, 21 Lower Kent Ridge 
      Road, Singapore, 119077, Singapore.
AD  - Department of Chemistry, National University of Singapore, 3 Science Drive 3, 
      Singapore, 117543, Singapore.
FAU - Zulkifli, Farah Iffah Bte
AU  - Zulkifli FIB
AD  - Department of Chemistry, National University of Singapore, 3 Science Drive 3, 
      Singapore, 117543, Singapore.
FAU - Lee, Hian Kee
AU  - Lee HK
AUID- ORCID: 0000-0002-5664-9509
AD  - NUS Graduate School for Integrative Sciences and Engineering, National University 
      of Singapore, University Hall, Tan Chin Tuan Wing #04-02, 21 Lower Kent Ridge 
      Road, Singapore, 119077, Singapore. chmleehk@nus.edu.sg.
AD  - Department of Chemistry, National University of Singapore, 3 Science Drive 3, 
      Singapore, 117543, Singapore. chmleehk@nus.edu.sg.
AD  - National University of Singapore Environmental Research Institute, T-Lab Building 
      #02-01, 5A Engineering Drive 1, Singapore, 117411, Singapore. 
      chmleehk@nus.edu.sg.
LA  - eng
GR  - 143-000-023-001/National University of Singapore/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210107
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
SB  - IM
OTO - NOTNLM
OT  - Chlorophenoxy acid
OT  - Environmental water
OT  - Halogenated compounds
OT  - Herbicide determination
OT  - Liquid chromatography-tandem mass spectrometry
OT  - Microextraction
OT  - Porous nanomaterials
OT  - Sample preparation
EDAT- 2021/01/09 06:00
MHDA- 2021/01/09 06:01
CRDT- 2021/01/08 06:14
PHST- 2020/09/05 00:00 [received]
PHST- 2020/11/19 00:00 [accepted]
PHST- 2021/01/08 06:14 [entrez]
PHST- 2021/01/09 06:00 [pubmed]
PHST- 2021/01/09 06:01 [medline]
AID - 10.1007/s00604-020-04661-5 [pii]
AID - 10.1007/s00604-020-04661-5 [doi]
PST - epublish
SO  - Mikrochim Acta. 2021 Jan 7;188(2):30. doi: 10.1007/s00604-020-04661-5.