PMID- 33417039 OWN - NLM STAT- MEDLINE DCOM- 20210614 LR - 20221109 IS - 1432-5233 (Electronic) IS - 0940-5429 (Linking) VI - 58 IP - 6 DP - 2021 Jun TI - The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. PG - 671-685 LID - 10.1007/s00592-020-01648-9 [doi] AB - AIMS: Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies. METHODS: We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16. RESULTS: A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I(2)=82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I(2)=98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I(2)=98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I(2)=98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I(2)=98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I(2)=91.2%). CONCLUSION: Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease. FAU - You, Yue AU - You Y AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. moonyou1908@163.com. FAU - Liu, Zhizhen AU - Liu Z AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. lzz@fjtcm.edu.cn. AD - National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. lzz@fjtcm.edu.cn. AD - Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian, China. lzz@fjtcm.edu.cn. AD - Key Laboratory of Orthopedics and Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Ministry of Education, Fuzhou, China. lzz@fjtcm.edu.cn. FAU - Chen, Yannan AU - Chen Y AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. FAU - Xu, Ying AU - Xu Y AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. AD - National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. AD - Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian, China. AD - Key Laboratory of Orthopedics and Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Ministry of Education, Fuzhou, China. FAU - Qin, Jiawei AU - Qin J AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. FAU - Guo, Shuai AU - Guo S AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. FAU - Huang, Jia AU - Huang J AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. AD - Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian, China. AD - Key Laboratory of Orthopedics and Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Ministry of Education, Fuzhou, China. FAU - Tao, Jing AU - Tao J AUID- ORCID: 0000-0001-9751-5294 AD - College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. AD - National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. AD - Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian, China. AD - Key Laboratory of Orthopedics and Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Ministry of Education, Fuzhou, China. LA - eng GR - 2019YFC1710301/Key Technologies Research and Development Program/ GR - 2018Y2002/Fujian Provincial Department of Science and Technology/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20210108 PL - Germany TA - Acta Diabetol JT - Acta diabetologica JID - 9200299 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Alzheimer Disease/epidemiology/etiology MH - Asia/epidemiology MH - China/epidemiology MH - Cognitive Dysfunction/*epidemiology/etiology MH - Diabetes Mellitus, Type 2/complications/*epidemiology/psychology MH - Europe/epidemiology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prevalence MH - Risk Factors OTO - NOTNLM OT - Dementia OT - Mild cognitive impairment OT - Prevalence OT - Type 2 diabetes mellitus EDAT- 2021/01/09 06:00 MHDA- 2021/06/16 06:00 CRDT- 2021/01/08 12:14 PHST- 2020/08/19 00:00 [received] PHST- 2020/11/28 00:00 [accepted] PHST- 2021/01/09 06:00 [pubmed] PHST- 2021/06/16 06:00 [medline] PHST- 2021/01/08 12:14 [entrez] AID - 10.1007/s00592-020-01648-9 [pii] AID - 10.1007/s00592-020-01648-9 [doi] PST - ppublish SO - Acta Diabetol. 2021 Jun;58(6):671-685. doi: 10.1007/s00592-020-01648-9. Epub 2021 Jan 8.