PMID- 33418107
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 1873-4596 (Electronic)
IS  - 0891-5849 (Linking)
VI  - 164
DP  - 2021 Feb 20
TI  - One-electron reduction triggered nitric oxide release for ischemia-reperfusion 
      protection.
PG  - 13-19
LID - S0891-5849(20)32116-X [pii]
LID - 10.1016/j.freeradbiomed.2020.12.443 [doi]
AB  - Nitric oxide donors (NODs) are indispensable in biological research and disease 
      treatment. NODs had been utilized to treat cardiovascular diseases in clinic and 
      many others are under trial. Thiols are typically required for these donors to 
      release NO. Yet, their mechanism is complex and often lead to resistance. Herein, 
      we reported that N-nitrosated electron-deficient dyes are capable of NO release 
      with one-electron reduction. A fluorophore is generated simultaneously, whose 
      fluorescence is harnessed to monitor the profile of NO release. Through 
      electrochemical and spectral studies, NOD f3 was found to exhibit good 
      biocompatibility and high reduction efficiency and its potentials in 
      cell-protection in oxygen and glucose deprivation (OGD) models were showcased 
      with endothelial cells. This work aims at offering a new approach to design 
      reduction-triggered NOD, which have therapeutic potentials in 
      ischemia-reperfusion.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Xu, Xiu
AU  - Xu X
AD  - State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of 
      Chemical Biology, School of Pharmacy, East China University of Science and 
      Technology, Shanghai, 200237, China.
FAU - Sun, Meiling
AU  - Sun M
AD  - Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, 
      Nanjing Medical University, Nanjing, 211166, China.
FAU - Luo, Xiao
AU  - Luo X
AD  - School of Chemistry and Molecular Engineering, East China Normal University, 
      Dongchuan Road 500, Shanghai, 200241, China.
FAU - Zhang, Ziqian
AU  - Zhang Z
AD  - Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi 
      University of Chinese Medicine, Nanning, 530200, China.
FAU - Su, Lin
AU  - Su L
AD  - State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of 
      Chemical Biology, School of Pharmacy, East China University of Science and 
      Technology, Shanghai, 200237, China.
FAU - Cui, Lingfei
AU  - Cui L
AD  - School of Chemistry and Molecular Engineering, East China University of Science 
      and Technology, Shanghai, 200237, China.
FAU - Zhu, Zhihui
AU  - Zhu Z
AD  - Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, 
      Nanjing Medical University, Nanjing, 211166, China.
FAU - Lu, Xicun
AU  - Lu X
AD  - State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of 
      Chemical Biology, School of Pharmacy, East China University of Science and 
      Technology, Shanghai, 200237, China.
FAU - Wang, Rui
AU  - Wang R
AD  - State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of 
      Chemical Biology, School of Pharmacy, East China University of Science and 
      Technology, Shanghai, 200237, China.
FAU - Han, Feng
AU  - Han F
AD  - Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, 
      Nanjing Medical University, Nanjing, 211166, China. Electronic address: 
      fenghan169@njmu.edu.cn.
FAU - Qian, Xuhong
AU  - Qian X
AD  - State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of 
      Chemical Biology, School of Pharmacy, East China University of Science and 
      Technology, Shanghai, 200237, China.
FAU - Yang, Youjun
AU  - Yang Y
AD  - State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of 
      Chemical Biology, School of Pharmacy, East China University of Science and 
      Technology, Shanghai, 200237, China. Electronic address: youjunyang@ecust.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210105
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Electrons
MH  - Endothelial Cells
MH  - Humans
MH  - Ischemia
MH  - *Nitric Oxide
MH  - Reperfusion
MH  - *Reperfusion Injury/prevention & control
OTO - NOTNLM
OT  - Fluorescence
OT  - Ischemia-reperfusion protection
OT  - N-nitrosated dye
OT  - Nitric oxide
OT  - Reduction-triggered release
EDAT- 2021/01/09 06:00
MHDA- 2021/06/25 06:00
CRDT- 2021/01/08 20:13
PHST- 2020/11/05 00:00 [received]
PHST- 2020/12/23 00:00 [revised]
PHST- 2020/12/29 00:00 [accepted]
PHST- 2021/01/09 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2021/01/08 20:13 [entrez]
AID - S0891-5849(20)32116-X [pii]
AID - 10.1016/j.freeradbiomed.2020.12.443 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2021 Feb 20;164:13-19. doi: 
      10.1016/j.freeradbiomed.2020.12.443. Epub 2021 Jan 5.