PMID- 33418744
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210111
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 4
IP  - 2
DP  - 2018 Feb 12
TI  - Polyacrylic Acid Functionalized Co(0.85)Se Nanoparticles: An Ultrasmall 
      pH-Responsive Nanocarrier for Synergistic Photothermal-Chemo Treatment of Cancer.
PG  - 547-557
LID - 10.1021/acsbiomaterials.7b00878 [doi]
AB  - To surmount the challenges of limited drug penetration and therapeutic resistance 
      in solid tumors, stimuli-responsive nanocarrier-based drug delivery systems 
      (DDSs) with relatively small sizes are inherently favorable for combined 
      treatment of cancerous cells. In this work, poly(acrylic acid) (PAA) 
      functionalized Co(0.85)Se nanoparticles (PAA-Co(0.85)Se NPs) were synthesized 
      through an ambient aqueous precipitating approach for synergistic 
      photothermal-chemo treatment of cancer. The obtained PAA-Co(0.85)Se NPs possess 
      ultrasmall size (8.2 +/- 2.6 nm), considerable near-infrared (NIR) light 
      absorption, high photothermal transforming efficiency (45.2%) and low 
      cytotoxicity, all of which are beneficial for localized photothermal ablation of 
      cancer cells. Doxorubicin hydrochloride (DOX.HCl) was then successfully loaded on 
      PAA-Co(0.85)Se NPs with a loading capacity up to 8.3% to form PAA-Co(0.85)Se-DOX 
      composites, which exhibited an exciting acidic pH-responsive drug release 
      property due to the protonation of amino groups in DOX and carboxyl groups in PAA 
      molecules. As expected, when HeLa cells were treated with PAA-Co(0.85)Se-DOX NPs 
      as well as NIR laser irradiation, a significant synergistic cell-killing effect 
      was observed, greatly improving the treatment efficiency. Thus, this work 
      presents novel insight into the design of ultrasmall stimuli-responsive 
      nanocarrier-based DDSs for synergistic photothermal-chemo treatment of cancer 
      cells.
FAU - Ma, Yan
AU  - Ma Y
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
FAU - Wang, Xianwen
AU  - Wang X
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
FAU - Chen, Huajian
AU  - Chen H
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
FAU - Miao, Zhaohua
AU  - Miao Z
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
FAU - He, Gang
AU  - He G
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
FAU - Zhou, Junhong
AU  - Zhou J
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
FAU - Zha, Zhengbao
AU  - Zha Z
AUID- ORCID: 0000-0003-3646-4969
AD  - School of Biological and Medical Engineering, Hefei University of Technology, No. 
      193 Tunxi road, Hefei, Anhui 230009, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20180110
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - cancer cells
OT  - cobalt selenide
OT  - pH-responsive
OT  - photothermal-chemo
EDAT- 2018/02/12 00:00
MHDA- 2018/02/12 00:01
CRDT- 2021/01/09 01:00
PHST- 2021/01/09 01:00 [entrez]
PHST- 2018/02/12 00:00 [pubmed]
PHST- 2018/02/12 00:01 [medline]
AID - 10.1021/acsbiomaterials.7b00878 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2018 Feb 12;4(2):547-557. doi: 
      10.1021/acsbiomaterials.7b00878. Epub 2018 Jan 10.