PMID- 33419180
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210218
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 6
TI  - Involvements of Hyperhomocysteinemia in Neurological Disorders.
LID - 10.3390/metabo11010037 [doi]
LID - 37
AB  - Homocysteine (HCY), a physiological amino acid formed when proteins break down, 
      leads to a pathological condition called hyperhomocysteinemia (HHCY), when it is 
      over a definite limit. It is well known that an increase in HCY levels in blood, 
      can contribute to arterial damage and several cardiovascular disease, but the 
      knowledge about the relationship between HCY and brain disorders is very poor. 
      Recent studies demonstrated that an alteration in HCY metabolism or a deficiency 
      in folate or vitamin B12 can cause altered methylation and/or redox potentials, 
      that leads to a modification on calcium influx in cells, or into an accumulation 
      in amyloid and/or tau protein involving a cascade of events that culminate in 
      apoptosis, and, in the worst conditions, neuronal death. The present review will 
      thus summarize how much is known about the possible role of HHCY in 
      neurodegenerative disease.
FAU - Cordaro, Marika
AU  - Cordaro M
AUID- ORCID: 0000-0002-3980-0043
AD  - Department of Biomedical, Dental and Morphological and Functional Imaging, 
      University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
FAU - Siracusa, Rosalba
AU  - Siracusa R
AUID- ORCID: 0000-0001-7868-2505
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Fusco, Roberta
AU  - Fusco R
AUID- ORCID: 0000-0003-0223-1403
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Cuzzocrea, Salvatore
AU  - Cuzzocrea S
AUID- ORCID: 0000-0001-6131-3690
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
AD  - Department of Pharmacological and Physiological Science, Saint Louis University 
      School of Medicine, Saint Louis, MO 63104, USA.
FAU - Di Paola, Rosanna
AU  - Di Paola R
AUID- ORCID: 0000-0001-6725-8581
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Impellizzeri, Daniela
AU  - Impellizzeri D
AUID- ORCID: 0000-0001-9492-3161
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210106
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC7825518
OTO - NOTNLM
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - pathology
OT  - physiology
OT  - target
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/10 06:00
MHDA- 2021/01/10 06:01
PMCR- 2021/01/06
CRDT- 2021/01/09 01:02
PHST- 2020/11/27 00:00 [received]
PHST- 2020/12/27 00:00 [revised]
PHST- 2021/01/01 00:00 [accepted]
PHST- 2021/01/09 01:02 [entrez]
PHST- 2021/01/10 06:00 [pubmed]
PHST- 2021/01/10 06:01 [medline]
PHST- 2021/01/06 00:00 [pmc-release]
AID - metabo11010037 [pii]
AID - metabolites-11-00037 [pii]
AID - 10.3390/metabo11010037 [doi]
PST - epublish
SO  - Metabolites. 2021 Jan 6;11(1):37. doi: 10.3390/metabo11010037.