PMID- 33419272
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210218
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 10
IP  - 12
DP  - 2020 Dec 20
TI  - Association between Systemic Antioxidant Capacity and Retinal Vessel Diameters in 
      Patients with Primary-Open Angle Glaucoma.
LID - 10.3390/life10120364 [doi]
LID - 364
AB  - The retinal vessel narrowing may be implicated in the pathogenesis of glaucoma; 
      however, the association between systemic oxidative stress and retinal vessel 
      diameter remains largely unknown. We examined the relationship between serum 
      oxidative stress markers and retinal vessel diameters in eyes with primary 
      open-angle glaucoma (POAG) and cataract, using central retinal artery equivalent 
      (CRAE) and central retinal vein equivalent (CRVE). We included 66 eyes of 66 
      patients with POAG (37 men, 29 women; 65.4 +/- 11.7 years) and 20 eyes of 20 
      patients with cataract (7 men, 13 women; 69.4 +/- 9.0 years) as the controls. The 
      CRAE (p < 0.0001), CRVE (p < 0.0001), and serum biological antioxidant potential 
      (BAP) (p = 0.0419) were significantly lower in the POAG group compared to the 
      controls. The BAP showed significant correlation both with CRAE (rho = 0.2148, p = 
      0.0471) and systolic blood pressure (rho = -0.2431, p = 0.0241), while neither 
      Diacron reactive oxygen metabolites nor sulfhydryl test correlated with them. The 
      multivariate analyses indicated that age, best corrected visual acuity, and BAP 
      were independent factors for CRAE or CRVE. The present study suggested that lower 
      systemic antioxidant capacity was significantly associated with the intraocular 
      pressure-independent vascular narrowing in POAG patients. This study provided a 
      novel insight into the pathophysiology of glaucoma and highlighted the clinical 
      impact on systemic antioxidant treatment for patients with glaucoma.
FAU - Takayanagi, Yuji
AU  - Takayanagi Y
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 
      693-8501, Japan.
FAU - Takai, Yasuyuki
AU  - Takai Y
AUID- ORCID: 0000-0003-3881-3624
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 
      693-8501, Japan.
FAU - Kaidzu, Sachiko
AU  - Kaidzu S
AUID- ORCID: 0000-0002-3324-6678
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 
      693-8501, Japan.
FAU - Tanito, Masaki
AU  - Tanito M
AUID- ORCID: 0000-0001-6512-7203
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 
      693-8501, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201220
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC7767320
OTO - NOTNLM
OT  - Diacron reactive oxygen metabolites (dROM)
OT  - antioxidants
OT  - biological antioxidant potential (BAP)
OT  - central retinal artery equivalent
OT  - central retinal vein equivalent
OT  - intraocular pressure
OT  - oxidative stress
OT  - primary open-angle glaucoma
OT  - redox status
OT  - sulfhydryl (SH) test
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/10 06:00
MHDA- 2021/01/10 06:01
PMCR- 2020/12/20
CRDT- 2021/01/09 01:02
PHST- 2020/11/16 00:00 [received]
PHST- 2020/12/16 00:00 [revised]
PHST- 2020/12/18 00:00 [accepted]
PHST- 2021/01/09 01:02 [entrez]
PHST- 2021/01/10 06:00 [pubmed]
PHST- 2021/01/10 06:01 [medline]
PHST- 2020/12/20 00:00 [pmc-release]
AID - life10120364 [pii]
AID - life-10-00364 [pii]
AID - 10.3390/life10120364 [doi]
PST - epublish
SO  - Life (Basel). 2020 Dec 20;10(12):364. doi: 10.3390/life10120364.