PMID- 33419373
OWN - NLM
STAT- MEDLINE
DCOM- 20210409
LR  - 20240330
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 24
DP  - 2020 Dec 20
TI  - The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.
LID - 10.3390/ijms21249739 [doi]
LID - 9739
AB  - Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular 
      matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost 
      every component of the ECM. The degradation of the ECM is of great importance, 
      since it is related to embryonic development and angiogenesis. It is also 
      involved in cell repair and the remodeling of tissues. When the expression of 
      MMPs is altered, it can generate the abnormal degradation of the ECM. This is the 
      initial cause of the development of chronic degenerative diseases and vascular 
      complications generated by diabetes. In addition, this process has an association 
      with neurodegeneration and cancer progression. Within the ECM, the tissue 
      inhibitors of MMPs (TIMPs) inhibit the proteolytic activity of MMPs. TIMPs are 
      important regulators of ECM turnover, tissue remodeling, and cellular behavior. 
      Therefore, TIMPs (similar to MMPs) modulate angiogenesis, cell proliferation, and 
      apoptosis. An interruption in the balance between MMPs and TIMPs has been 
      implicated in the pathophysiology and progression of several diseases. This 
      review focuses on the participation of both MMPs (e.g., MMP-2 and MMP-9) and 
      TIMPs (e.g., TIMP-1 and TIMP-3) in physiological processes and on how their 
      abnormal regulation is associated with human diseases. The inclusion of current 
      strategies and mechanisms of MMP inhibition in the development of new therapies 
      targeting MMPs was also considered.
FAU - Cabral-Pacheco, Griselda A
AU  - Cabral-Pacheco GA
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Garza-Veloz, Idalia
AU  - Garza-Veloz I
AUID- ORCID: 0000-0002-6307-1696
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Castruita-De la Rosa, Claudia
AU  - Castruita-De la Rosa C
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Ramirez-Acuna, Jesus M
AU  - Ramirez-Acuna JM
AUID- ORCID: 0000-0002-9183-2034
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Perez-Romero, Braulio A
AU  - Perez-Romero BA
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Guerrero-Rodriguez, Jesus F
AU  - Guerrero-Rodriguez JF
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Martinez-Avila, Nadia
AU  - Martinez-Avila N
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
FAU - Martinez-Fierro, Margarita L
AU  - Martinez-Fierro ML
AUID- ORCID: 0000-0003-1478-9068
AD  - Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de 
      la Salud, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas 
      98160, Mexico.
LA  - eng
GR  - NA/Programa de Doctorado en Ciencias con Orientacion en Medicina Molecular/
PT  - Journal Article
PT  - Review
DEP - 20201220
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-3)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Chronic Disease/prevention & control
MH  - Diabetes Mellitus/*genetics/pathology
MH  - Extracellular Matrix/genetics
MH  - Humans
MH  - Matrix Metalloproteinase 2/*genetics
MH  - Matrix Metalloproteinase 9/*genetics
MH  - Matrix Metalloproteinases/genetics
MH  - Neovascularization, Physiologic/genetics
MH  - Tissue Inhibitor of Metalloproteinase-1/*genetics
MH  - Tissue Inhibitor of Metalloproteinase-3
MH  - Tissue Inhibitor of Metalloproteinases/genetics
PMC - PMC7767220
OTO - NOTNLM
OT  - human diseases
OT  - matrix metalloproteinases
OT  - metalloproteinase inhibitors
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/01/10 06:00
MHDA- 2021/04/10 06:00
PMCR- 2020/12/20
CRDT- 2021/01/09 01:02
PHST- 2020/11/06 00:00 [received]
PHST- 2020/12/10 00:00 [revised]
PHST- 2020/12/18 00:00 [accepted]
PHST- 2021/01/09 01:02 [entrez]
PHST- 2021/01/10 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/12/20 00:00 [pmc-release]
AID - ijms21249739 [pii]
AID - ijms-21-09739 [pii]
AID - 10.3390/ijms21249739 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Dec 20;21(24):9739. doi: 10.3390/ijms21249739.