PMID- 33419582
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 52
IP  - 4
DP  - 2021 May
TI  - Long Noncoding RNA MIAT Regulates the Process of Laryngeal Squamous Cell 
      Carcinoma Through Regulation of miR-147a/BCOR.
PG  - 371-379
LID - S0188-4409(20)32242-6 [pii]
LID - 10.1016/j.arcmed.2020.12.001 [doi]
AB  - BACKGROUND: Myocardial infarction associated transcript (MIAT) is a long 
      non-coding RNA (lncRNA) that can play oncogenic role in different kinds of 
      cancers. However, its role in laryngeal squamous cell carcinoma (LSCC) remains 
      unknown. AIM: The study aimed to explore the effect of MIAT/miR-147a/BCOR axis on 
      LSCC progression. METHODS: The expression pattern of MIAT, miR-147a and BCOR in 
      LSCC samples and cells was identified through qRT-PCR. The proliferation of LSCC 
      cells was assessed by colony formation assay and CCK-8 assays. Transwell assays 
      were implemented to test the migratory and invasive abilities of LSCC cells. 
      Proteins associated with migration and epithelial-mesenchymal transition were 
      probed in transfected LSCC cells by western blot. The interaction of miR-147a 
      with MIAT or BCOR was analyzed by luciferase reporter assays, RNA pulls down 
      assays and Ago2-RIP assays. RESULTS: High MIAT expression was closely correlated 
      with unfavorable prognosis. MIAT knockdown inhibited cell proliferation, 
      migration, invasion and EMT progress in LSCC. MIAT acted as a miR-147a sponge to 
      increase the expression of BCOR. Silencing of MIAT suppressed LSCC progression 
      through miR-147a/BCOR axis. CONCLUSION: MIAT acts as an oncogene by controlling 
      miR-147a/BCOR axis in LSCC.
CI  - Copyright (c) 2020 IMSS. Published by Elsevier Inc. All rights reserved.
FAU - Song, Daoliang
AU  - Song D
AD  - Otolaryngology Head and Neck Surgery, Zibo Central Hospital, Zibo, Shandong, 
      China.
FAU - Wu, Shuo
AU  - Wu S
AD  - The Third Affiliated Hospital, Sun Yat-sen University School of Life Science, Sun 
      Yat-sen University, Tianhe District, Guangzhou, Guangdong, China.
FAU - Hu, Huihua
AU  - Hu H
AD  - Department of Oncology, Suizhou Hospital, Hubei University of Medicine, Zengdu 
      District, Suizhou, Hubei, China.
FAU - Dai, Xinyi
AU  - Dai X
AD  - The Third Affiliated Hospital, Sun Yat-sen University School of Life Science, Sun 
      Yat-sen University, Tianhe District, Guangzhou, Guangdong, China.
FAU - Wang, Xiaocong
AU  - Wang X
AD  - Department of Oncology, Suizhou Hospital, Hubei University of Medicine, Zengdu 
      District, Suizhou, Hubei, China. Electronic address: 
      sanjeev.ahuja@astrazeneca.com.
LA  - eng
PT  - Journal Article
DEP - 20210105
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (BCOR protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Cell Proliferation
MH  - Gene Expression Regulation, Neoplastic
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics
MH  - *MicroRNAs/genetics
MH  - Proto-Oncogene Proteins
MH  - *RNA, Long Noncoding/genetics
MH  - Repressor Proteins
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - BCOR
OT  - Laryngeal squamous cell carcinoma
OT  - MIAT
OT  - miR-147a
EDAT- 2021/01/10 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/01/09 05:29
PHST- 2019/11/10 00:00 [received]
PHST- 2020/11/19 00:00 [revised]
PHST- 2020/12/03 00:00 [accepted]
PHST- 2021/01/10 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/01/09 05:29 [entrez]
AID - S0188-4409(20)32242-6 [pii]
AID - 10.1016/j.arcmed.2020.12.001 [doi]
PST - ppublish
SO  - Arch Med Res. 2021 May;52(4):371-379. doi: 10.1016/j.arcmed.2020.12.001. Epub 
      2021 Jan 5.