PMID- 33419624
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20220323
IS  - 1436-2023 (Electronic)
IS  - 0949-2658 (Linking)
VI  - 27
IP  - 2
DP  - 2022 Mar
TI  - Association between type 2 diabetes status and osteoarthritis in adults aged >/= 50 
      years.
PG  - 486-491
LID - S0949-2658(20)30364-X [pii]
LID - 10.1016/j.jos.2020.12.001 [doi]
AB  - BACKGROUND: Increasingly, studies have addressed the possible association between 
      type 2 diabetes mellitus (T2DM) and osteoarthritis (OA), although this remains an 
      issue of controversy. Our aim in this study was to investigate the association 
      between T2DM and OA among 7781 adults >/=50 years of age, through a cross-sectional 
      analysis of the National Health and Nutrition Examination Survey from 2011 
      through 2018. METHODS: Amultivariable logistic regression model was used to 
      evaluate the association between T2DM or prediabetes status and OA, with subgroup 
      analyses performed, stratified by age, sex, body mass index (BMI), and race. 
      RESULTS: Of the 7781 participants enrolled, 1567 (20.1%) had T2DM, 3131 (40.3%) 
      had prediabetes, and 3083 (39.6%) were normal. A significant positive association 
      was identified between T2DM and OA, after adjusting for age, sex, and race. This 
      association, however, was no longer significant after adjusting for BMI. In the 
      fully-adjusted model, there were no significant association between T2DM and OA. 
      CONCLUSIONS: Our findings showed no association between T2DM and OA. The 
      association between T2DM and OA can be strongly confounded by BMI.
CI  - Copyright (c) 2021 The Japanese Orthopaedic Association. Published by Elsevier B.V. 
      All rights reserved.
FAU - Zhu, Zhongxin
AU  - Zhu Z
AD  - Department of Osteoporosis Care and Control, The First People's Hospital of 
      Xiaoshan District, Hangzhou, Zhejiang, 311200, China.
FAU - Sheng, Xian
AU  - Sheng X
AD  - Department of Cancer Medicine, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang, 311200, China.
FAU - Zhang, JingJing
AU  - Zhang J
AD  - The First College of Clinical Medicine, Zhejiang Chinese Medical University, 
      Hangzhou, Zhejiang, 310053, China.
FAU - Yao, Xiaocong
AU  - Yao X
AD  - Department of Osteoporosis Care and Control, The First People's Hospital of 
      Xiaoshan District, Hangzhou, Zhejiang, 311200, China. Electronic address: 
      hzyaoxiaocong@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210105
PL  - Japan
TA  - J Orthop Sci
JT  - Journal of orthopaedic science : official journal of the Japanese Orthopaedic 
      Association
JID - 9604934
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology
MH  - Humans
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - *Osteoarthritis/epidemiology
COIS- Declaration of competing interest The authors declare that they have no competing 
      interests.
EDAT- 2021/01/10 06:00
MHDA- 2022/03/24 06:00
CRDT- 2021/01/09 05:29
PHST- 2020/08/17 00:00 [received]
PHST- 2020/10/23 00:00 [revised]
PHST- 2020/12/03 00:00 [accepted]
PHST- 2021/01/10 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2021/01/09 05:29 [entrez]
AID - S0949-2658(20)30364-X [pii]
AID - 10.1016/j.jos.2020.12.001 [doi]
PST - ppublish
SO  - J Orthop Sci. 2022 Mar;27(2):486-491. doi: 10.1016/j.jos.2020.12.001. Epub 2021 
      Jan 5.