PMID- 33420569 OWN - NLM STAT- MEDLINE DCOM- 20210205 LR - 20210205 IS - 1432-1963 (Electronic) IS - 0172-8113 (Linking) VI - 42 IP - 1 DP - 2021 Feb TI - [Interstitial lung disease associated with connective tissue disease]. PG - 4-10 LID - 10.1007/s00292-020-00902-9 [doi] AB - Interstitial lung disease (ILD) is the most frequent organ manifestation in rheumatic autoimmune disease. Depending on the underlying autoimmune disease, differently pronounced affections of small airways, interstitial parenchyma, and vessels are found. The group of rheumatic autoimmune diseases mainly includes connective tissue diseases (CTDs), also known as collagen vascular diseases, such as rheumatoid arthritis (RA), systemic sclerosis, (SSc), systemic lupus erythematosus, primary Sjogren's syndrome, idiopathic inflammatory myositis (IIM), and interstitial pneumonia with autoimmune features (IPAF). Frequency and manifestations of parenchymal lung disorders are described clinically, radiologically, and morphologically in these entities. For the precise diagnosis and for the differentiation between the wide range of parenchymal disorders with known possible cause or with unknown origin, also called unclassifiable or idiopathic interstitial pneumonias (IIPs), high resolution computed tomography (HRCT) findings represent the diagnostic gold standard. A transbronchial biopsy, surgical biopsy, or cryobiopsy will be used in unclassifiable findings to confirm a definitive histological confirmation. A precise diagnosis of these ILDs is crucial since the different pathologies that encompass ILD have different therapeutic options. In this sense, the participation of a pneumologist, rheumatologist, radiologist, and pathologist become essential in the multidisciplinary evolution of ILD. FAU - Fisseler-Eckhoff, Annette AU - Fisseler-Eckhoff A AD - Institut fur Pathologie und Zytologie, Helios Dr. Horst Schmidt-Kliniken Wiesbaden GmbH, Ludwig Erhard Str. 100, 65199, Wiesbaden, Deutschland. annette.fisseler-eckhoff@helios-gesundheit.de. FAU - Marker-Hermann, Elisabeth AU - Marker-Hermann E AD - Klinik fur Rheumatologie, Klinische Immunologie und Nephrologie, Helios Dr. Horst Schmidt-Kliniken Wiesbaden, Wiesbaden, Deutschland. LA - ger PT - Journal Article PT - Review TT - Interstitielle Lungenparenchymveranderungen bei rheumatischen Systemerkrankungen. DEP - 20210108 PL - Germany TA - Pathologe JT - Der Pathologe JID - 8006541 SB - IM MH - *Autoimmune Diseases MH - *Connective Tissue Diseases MH - Humans MH - Lung/diagnostic imaging MH - *Lung Diseases, Interstitial MH - *Lupus Erythematosus, Systemic MH - Tomography, X-Ray Computed OTO - NOTNLM OT - CTD OT - Clinic OT - ILD OT - Pathology OT - Radiology EDAT- 2021/01/10 06:00 MHDA- 2021/02/07 06:00 CRDT- 2021/01/09 05:49 PHST- 2020/12/17 00:00 [accepted] PHST- 2021/01/10 06:00 [pubmed] PHST- 2021/02/07 06:00 [medline] PHST- 2021/01/09 05:49 [entrez] AID - 10.1007/s00292-020-00902-9 [pii] AID - 10.1007/s00292-020-00902-9 [doi] PST - ppublish SO - Pathologe. 2021 Feb;42(1):4-10. doi: 10.1007/s00292-020-00902-9. Epub 2021 Jan 8.