PMID- 33421444
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 172
DP  - 2021 Feb
TI  - Effect of background insulin therapy on cardiovascular outcomes with SGLT-2 
      inhibitors in type 2 diabetes: A meta-analysis of cardiovascular outcome trials.
PG  - 108648
LID - S0168-8227(21)00001-2 [pii]
LID - 10.1016/j.diabres.2021.108648 [doi]
AB  - Cardiovascular (CV) benefits of SGLT-2 inhibitors (SGLT-2i) have been consistent 
      in type 2 diabetes mellitus (T2DM). To find whether SGLT-2i show similar CV 
      effects with insulin therapy in T2DM, we conducted a trial-level meta-analysis of 
      CV outcome trials. This meta-analysis found SGLT-2i exert CV benefit, 
      irrespective of background insulin therapy.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Singh, Awadhesh Kumar
AU  - Singh AK
AD  - Department of Diabetes & Endocrinology, G.D Hospital & Diabetes Institute, 
      Kolkata, India. Electronic address: drawadheshkumarsingh@gmail.com.
FAU - Singh, Ritu
AU  - Singh R
AD  - Department of Diabetes & Endocrinology, G.D Hospital & Diabetes Institute, 
      Kolkata, India.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20210106
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
SB  - IM
MH  - Cardiovascular Diseases/*drug therapy
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Humans
MH  - Hypoglycemic Agents/pharmacology/*therapeutic use
MH  - Sodium-Glucose Transporter 2 Inhibitors/pharmacology/*therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cardiovascular death
OT  - Cardiovascular outcomes
OT  - Heart failure hospitalization
OT  - Insulin therapy
OT  - MACE outcomes
OT  - Meta-analysis
OT  - SGLT-2 inhibitors
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/01/10 06:00
MHDA- 2021/04/20 06:00
CRDT- 2021/01/09 20:07
PHST- 2020/11/20 00:00 [received]
PHST- 2020/12/18 00:00 [revised]
PHST- 2020/12/26 00:00 [accepted]
PHST- 2021/01/10 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2021/01/09 20:07 [entrez]
AID - S0168-8227(21)00001-2 [pii]
AID - 10.1016/j.diabres.2021.108648 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2021 Feb;172:108648. doi: 10.1016/j.diabres.2021.108648. 
      Epub 2021 Jan 6.