PMID- 33423477
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210114
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 5
IP  - 12
DP  - 2019 Dec 9
TI  - Crystal-Seeded Growth of pH-Responsive Metal-Organic Frameworks for Enhancing 
      Encapsulation, Stability, and Bioactivity of Hydrophobicity Compounds.
PG  - 6581-6589
LID - 10.1021/acsbiomaterials.9b01070 [doi]
AB  - Zeolitic imidazolate framework-L (ZIF-L) could effectively improve the stability, 
      controlled release, and anticancer activity of natural hydrophobicity drugs in 
      drug delivery systems (DDSs). A simple and universal strategy was developed to 
      prepare the curcumin-loaded ZIF-L (CCM@ZIF-L) by the antisolvent coprecipitation 
      method, which was different from the traditional approaches. The microcrystal 
      molecules of curcumin were used as the core of ZIF-L growth to form CCM@ZIF-L, 
      which has a very high drug encapsulation efficiency of 98.21% and a regular leaf 
      or cruciate flower-like structure. The formation of CCM@ZIF-L with a distinct 
      composite structure was supported by scanning electron microscopy, transmission 
      electron microscopy, Fourier-transform infrared, powder X-ray diffraction, and 
      zeta-potential. Because of the protective effect of ZIF-L, CCM@ZIF-L exhibited 
      excellent stability and about a 5-fold increase in temperature stability over 
      free curcumin. CCM@ZIF-L exhibited controlled drug release behavior in simulated 
      in vitro tumor microenvironments (almost 81.2% drug release over a period of 72 
      h). Furthermore, confocal laser scanning microscopy results and cytotoxicity 
      experiments confirmed that the encapsulated curcumin showed a significant 
      improvement in cellular uptake and anticancer activity against A549 cancer cells. 
      Moreover, the curcumin encapsulated in ZIF-L exhibited remarkable cellular 
      antioxidant activity based on MGC-803 cell models. This work presents a novel 
      approach to solve the drug loading problem by employing ZIF-L and exhibits 
      enormous potential of ZIF-L as an effective DDS in cancer treatments.
FAU - Liu, Zexun
AU  - Liu Z
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, P. R. China.
FAU - Wu, Qiao
AU  - Wu Q
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, P. R. China.
FAU - He, Jie
AU  - He J
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, P. R. China.
FAU - Vriesekoop, Frank
AU  - Vriesekoop F
AD  - Department of Food Technology and Innovation, Harper Adams University, Newport 
      TF10 8NB, Shropshire, England.
FAU - Liang, Hao
AU  - Liang H
AUID- ORCID: 0000-0002-4799-882X
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20191126
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - ZIF-L
OT  - cancer treatment
OT  - drug delivery
OT  - microcrystal of curcumin
OT  - pH-responsive
EDAT- 2019/12/09 00:00
MHDA- 2019/12/09 00:01
CRDT- 2021/01/11 05:22
PHST- 2021/01/11 05:22 [entrez]
PHST- 2019/12/09 00:00 [pubmed]
PHST- 2019/12/09 00:01 [medline]
AID - 10.1021/acsbiomaterials.9b01070 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2019 Dec 9;5(12):6581-6589. doi: 
      10.1021/acsbiomaterials.9b01070. Epub 2019 Nov 26.