PMID- 33424749
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Neural Correlates of Cognitive Dysfunctions in Cervical Spondylotic Myelopathy 
      Patients: A Resting-State fMRI Study.
PG  - 596795
LID - 10.3389/fneur.2020.596795 [doi]
LID - 596795
AB  - Cervical spondylotic myelopathy (CSM) is a common disease of the elderly that is 
      characterized by gait instability, sensorimotor deficits, etc. Recurrent symptoms 
      including memory loss, poor attention, etc. have also been reported in recent 
      studies. However, these have been rarely investigated in CSM patients. To 
      investigate the cognitive deficits and their correlation with brain functional 
      alterations, we conducted resting-state fMRI (rs-fMRI) signal variability. This 
      is a novel indicator in the neuroimaging field for assessing the regional neural 
      activity in CSM patients. Further, to explore the network changes in patients, 
      functional connectivity (FC) and graph theory analyses were performed. Compared 
      with the controls, the signal variabilities were significantly lower in the 
      widespread brain regions especially at the default mode network (DMN), visual 
      network, and somatosensory network. The altered inferior parietal lobule signal 
      variability positively correlated with the cognitive function level. Moreover, 
      the FC and the global efficiency of DMN increased in patients with CSM and 
      positively correlated with the cognitive function level. According to the study 
      results, (1) the cervical spondylotic myelopathy patients exhibited regional 
      neural impairments, which correlated with the severity of cognitive deficits in 
      the DMN brain regions, and (2) the increased FC and global efficiency of DMN can 
      compensate for the regional impairment.
CI  - Copyright (c) 2020 Zhao, Su, Chen, Sun, Liang and Xue.
FAU - Zhao, Rui
AU  - Zhao R
AD  - Department of Orthopedics Surgery, Tianjin Medical University General Hospital, 
      Tianjin, China.
FAU - Su, Qian
AU  - Su Q
AD  - Department of Molecular Imaging and Nuclear Medicine, National Clinical Research 
      Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, 
      Tianjin's Clinical Research Center for China, Tianjin Medical University Cancer 
      Institute and Hospital, Tianjin, China.
FAU - Chen, Zhao
AU  - Chen Z
AD  - Department of Orthopedics Surgery, Tianjin Medical University General Hospital, 
      Tianjin, China.
FAU - Sun, Haoran
AU  - Sun H
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Liang, Meng
AU  - Liang M
AD  - School of Medical Imaging, Tianjin Medical University, Tianjin, China.
FAU - Xue, Yuan
AU  - Xue Y
AD  - Department of Orthopedics Surgery, Tianjin Medical University General Hospital, 
      Tianjin, China.
AD  - Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University 
      General Hospital, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20201223
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7785814
OTO - NOTNLM
OT  - BOLD variability
OT  - cervical spondylotic myelopathy
OT  - cognitive deficits
OT  - default mode network
OT  - resting-state fMRI
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/12 06:00
MHDA- 2021/01/12 06:01
PMCR- 2020/12/23
CRDT- 2021/01/11 05:37
PHST- 2020/08/20 00:00 [received]
PHST- 2020/11/19 00:00 [accepted]
PHST- 2021/01/11 05:37 [entrez]
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/01/12 06:01 [medline]
PHST- 2020/12/23 00:00 [pmc-release]
AID - 10.3389/fneur.2020.596795 [doi]
PST - epublish
SO  - Front Neurol. 2020 Dec 23;11:596795. doi: 10.3389/fneur.2020.596795. eCollection 
      2020.