PMID- 33424752
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Viruses Causing Aseptic Meningitis: A Tertiary Medical Center Experience With a 
      Multiplex PCR Assay.
PG  - 602267
LID - 10.3389/fneur.2020.602267 [doi]
LID - 602267
AB  - Background: Central nervous system (CNS) infection is associated with high rates 
      of morbidity and mortality, and despite advancements in molecular testing, 
      aseptic meningitis remains challenging to diagnose. Aseptic meningitis cases are 
      often underreported worldwide, which impacts the quality of patient care. 
      Therefore, we aimed to assess the results of BioFire(R) FilmArray(R) 
      meningitis/encephalitis (ME) PCR panel, clinical characteristics, and etiologies 
      of aseptic meningitis patients. Methods: From January 2018 to January 2020, all 
      pediatric and adult patients in a large tertiary medical center who underwent 
      lumbar puncture and cerebrospinal fluid (CSF) testing by a ME multiplex PCR panel 
      and who fit the aseptic meningitis definition were retrospectively reviewed. 
      Results: Data were reviewed from 1,607 patients; 240 met the inclusion criteria 
      (54.6% males; 68.8% <4 years of age). The rate of detected viral causes of 
      aseptic meningitis was 40.4%; therefore, 59.6% of the patients remained with 
      unidentified etiology. Among the identified viral meningitis, enterovirus and 
      human herpesvirus 6 (HHV-6) were the most common (25 and 7.9%, respectively). The 
      median length of hospital stay was 6 days, and it was longer in patients with 
      unidentifiable aseptic meningitis (p < 0.0001). Conclusion: Aseptic meningitis is 
      common among suspected meningitis patients, but most cases remained of unknown 
      etiology. The most common identified viruses were enterovirus followed by HHV-6, 
      and there is predominance in males and the pediatric age group. These results 
      highlight that further research is needed to identify other etiologies and 
      possible additional viral pathogens for aseptic meningitis in the current 
      diagnostic methods.
CI  - Copyright (c) 2020 Aldriweesh, Shafaay, Alwatban, Alkethami, Aljuraisi, Bosaeed and 
      Alharbi.
FAU - Aldriweesh, Mohammed A
AU  - Aldriweesh MA
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
FAU - Shafaay, Edi A
AU  - Shafaay EA
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
FAU - Alwatban, Saud M
AU  - Alwatban SM
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
FAU - Alkethami, Obeid M
AU  - Alkethami OM
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
FAU - Aljuraisi, Faisal N
AU  - Aljuraisi FN
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
FAU - Bosaeed, Mohammad
AU  - Bosaeed M
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
AD  - Division of Infectious Diseases, Department of Medicine, King Abdulaziz Medical 
      City, Riyadh, Saudi Arabia.
FAU - Alharbi, Naif Khalaf
AU  - Alharbi NK
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Riyadh, Saudi Arabia.
AD  - Department of Infectious Disease Research, King Abdullah International Medical 
      Research Center, Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20201207
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7793969
OTO - NOTNLM
OT  - CNS infection
OT  - Filmarray ME panel
OT  - diagnostic PCR
OT  - enterovirus
OT  - herpesvirus
OT  - viral meningitis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/12 06:00
MHDA- 2021/01/12 06:01
PMCR- 2020/12/07
CRDT- 2021/01/11 05:37
PHST- 2020/09/02 00:00 [received]
PHST- 2020/11/10 00:00 [accepted]
PHST- 2021/01/11 05:37 [entrez]
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/01/12 06:01 [medline]
PHST- 2020/12/07 00:00 [pmc-release]
AID - 10.3389/fneur.2020.602267 [doi]
PST - epublish
SO  - Front Neurol. 2020 Dec 7;11:602267. doi: 10.3389/fneur.2020.602267. eCollection 
      2020.