PMID- 33425511
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 12
IP  - 12
DP  - 2020 Dec 6
TI  - Association of the JAZF1 Variant in Adults With a Parental History of Type 2 
      Diabetes Mellitus In Pakistan.
PG  - e11930
LID - 10.7759/cureus.11930 [doi]
LID - e11930
AB  - Background Type 2 diabetes mellitus (T2DM) is a chronic multifactorial condition 
      and quickly growing disease in Pakistan. Many genes together with Zinc finger 
      protein 1 (JAZF1) have already been described earlier in the literature but the 
      role of JAZF1 in this subset of the population is yet to define. This study was 
      aimed at identifying JAZF1 polymorphism and the risk of developing T2DM in 
      persons with a parental history of T2DM in the Pakistani population. Methods DNA 
      samples from 75 non-diabetic Pakistani participants with a family history of T2DM 
      and 75 controls were evaluated by using a polymerase chain reaction (PCR) and the 
      restriction fragment length polymorphism method. Results The alleles AA and 
      AG and the GG genotype of JAZF1 (rs864745) varied considerably in frequency 
      distribution between cases and control (p<0.05). The GG was independently and 
      significantly associated with cases who had a family history of T2DM [odds ratio 
      (OR) 2.6 (95% confidence interval (Cl) 1.3-5.1); p=0.005] while the AA allele was 
      significantly associated with controls without a family history of T2DM [odds 
      ratio (OR) 0.39 (95% confidence interval (Cl) 0.2-0.7); p=0.0059] and the allele 
      AG has no significance and was equally distributed among control and cases with 
      p-value=1.000. Conclusion Genotype GG of the JAZF1 variant was found 
      significantly associated with the risk of developing type 2 diabetes mellitus in 
      the Pakistani subset of the population.
CI  - Copyright (c) 2020, Zano et al.
FAU - Zano, Sheh
AU  - Zano S
AD  - Biochemistry, Ziauddin University, Karachi, PAK.
FAU - Rubab, Zil E
AU  - Rubab ZE
AD  - Biochemistry, Ziauddin University, Karachi, PAK.
FAU - Baig, Saeeda
AU  - Baig S
AD  - Biochemistry, Ziauddin University, Karachi, PAK.
FAU - Shahid, Moazzam A
AU  - Shahid MA
AD  - Biochemistry, Ziauddin University, Karachi, PAK.
FAU - Ahmad, Farah
AU  - Ahmad F
AD  - Community Health Sciences, Ziauddin University, Karachi, PAK.
FAU - Iqbal, Faizan
AU  - Iqbal F
AD  - Orthopaedics, Patel Hospital, Karachi, PAK.
LA  - eng
PT  - Journal Article
DEP - 20201206
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7785483
OTO - NOTNLM
OT  - family history
OT  - genetic variant
OT  - jazf1
OT  - multifactorial inheritance
OT  - pakistani population
OT  - systemic
OT  - type 2 diabetes mellitus
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/01/12 06:00
MHDA- 2021/01/12 06:01
PMCR- 2020/12/06
CRDT- 2021/01/11 05:40
PHST- 2021/01/11 05:40 [entrez]
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/01/12 06:01 [medline]
PHST- 2020/12/06 00:00 [pmc-release]
AID - 10.7759/cureus.11930 [doi]
PST - epublish
SO  - Cureus. 2020 Dec 6;12(12):e11930. doi: 10.7759/cureus.11930.