PMID- 33425756
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 10
DP  - 2020
TI  - Connexins in Lung Cancer and Brain Metastasis.
PG  - 599383
LID - 10.3389/fonc.2020.599383 [doi]
LID - 599383
AB  - Connexins (Cxs) are involved in the brain metastasis of lung cancer cells. Thus, 
      it is necessary to determine whether gap junction-forming Cxs are involved in the 
      communication between lung cancer cells and the host cells, such as endothelial 
      cells, forming the brain-blood-barrier, and cells in the central nervous system. 
      Data from multiple studies support that Cxs function as tumor suppressors during 
      lung cancer occurrence. However, recent evidence suggests that during metastasis 
      to the brain, cancer cells establish communication with the host. This review 
      discusses junctional or non-junctional hemichannel studies in lung cancer 
      development and brain metastasis, highlighting important unanswered questions and 
      controversies.
CI  - Copyright (c) 2020 Luo, Chen, Yang, Huang, Cardenas and Jiang.
FAU - Luo, Kai-Jun
AU  - Luo KJ
AD  - School of Life Sciences, Yunnan University, Kunming, China.
AD  - Key Laboratory of the University in Yunnan Province for International Cooperation 
      in Intercellular Communications and Regulations, Yunnan University, Kunming, 
      China.
FAU - Chen, Chang-Xu
AU  - Chen CX
AD  - School of Life Sciences, Yunnan University, Kunming, China.
AD  - Key Laboratory of the University in Yunnan Province for International Cooperation 
      in Intercellular Communications and Regulations, Yunnan University, Kunming, 
      China.
FAU - Yang, Jia-Peng
AU  - Yang JP
AD  - Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming 
      Medical University/Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, China.
AD  - Joint International Research Laboratory of Regional Tumor in High Altitude Area, 
      Kunming, China.
FAU - Huang, Yun-Chao
AU  - Huang YC
AD  - Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming 
      Medical University/Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, China.
AD  - Joint International Research Laboratory of Regional Tumor in High Altitude Area, 
      Kunming, China.
FAU - Cardenas, Eduardo R
AU  - Cardenas ER
AD  - Department of Biochemistry and Structural Biology, University of Texas Health 
      Science Center, San Antonio, TX, United States.
FAU - Jiang, Jean X
AU  - Jiang JX
AD  - Department of Biochemistry and Structural Biology, University of Texas Health 
      Science Center, San Antonio, TX, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201223
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC7786366
OTO - NOTNLM
OT  - astrocytes
OT  - connexin
OT  - endothelial cells
OT  - gap junction
OT  - hemichannel
OT  - lung cancer brain metastasis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/12 06:00
MHDA- 2021/01/12 06:01
PMCR- 2020/01/01
CRDT- 2021/01/11 05:41
PHST- 2020/08/27 00:00 [received]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2021/01/11 05:41 [entrez]
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/01/12 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2020.599383 [doi]
PST - epublish
SO  - Front Oncol. 2020 Dec 23;10:599383. doi: 10.3389/fonc.2020.599383. eCollection 
      2020.