PMID- 33425794 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220419 IS - 2287-8882 (Print) IS - 2287-903X (Electronic) IS - 2287-8882 (Linking) VI - 8 IP - 4 DP - 2020 Dec TI - Multiparametric magnetic resonance imaging and clinical variables: Which is the best combination to predict reclassification in active surveillance patients? PG - 167-172 LID - 10.1016/j.prnil.2020.05.003 [doi] AB - INTRODUCTION & OBJECTIVES: We tested the role of multiparametric magnetic resonance imaging (mpMRI) in disease reclassification and whether the combination of mpMRI and clinicopathological variables could represent the most accurate approach to predict the risk of reclassification during active surveillance. MATERIALS & METHODS: Three-hundred eighty-nine patients (pts) underwent mpMRI and subsequent confirmatory or follow-up biopsy according to the Prostate Cancer Research International Active Surveillance (PRIAS) protocol. Pts with negative (-) mpMRI underwent systematic random biopsy. Pts with positive (+) mpMRI [Prostate Imaging Reporting and Data System, version 2 (PI-RADS-V2) score >/=3] underwent targeted + systematic random biopsies. Multivariate analyses were used to create three models predicting the probability of reclassification [International Society of Urological Pathology >/= Grade Group 2 (GG2)]: a basic model including only clinical variables (age, prostate-specific antigen density, and number of positive cores at baseline), an Magnetic resonance imaging (MRI) model including only the PI-RADS score, and a full model including both the previous ones. The predictive accuracy (PA) of each model was quantified using the area under the curve. RESULTS: mpMRI negative (-) was recorded in 127 (32.6%) pts; mpMRI positive (+) was recorded in 262 pts: 72 (18.5%) had PI-RADS 3, 150 (38.6%) PI-RADS 4, and 40 (10.3%) PI-RADS 5 lesions. At a median follow-up of 12 months, 125 pts (32%) were reclassified to GG2 prostate cancer. The rate of reclassification to GG2 prostate cancer was 17%, 35%, 38%, and 52% for mpMRI (-), PI-RADS 3, 4, and 5, respectively (P < 0.001). The PA was 69% and 64% in the basic and MRI models, respectively. The full model had the best PA of 74%: older age (P = 0.023; Odds ratio (OR) = 1.040), prostate-specific antigen density (P = 0.037; OR = 1.324), number of positive cores at baseline (P = 0.001; OR = 1.441), and PI-RADS 3, 4, and 5 (overall P = 0.001; OR = 2.458, 3.007, and 3.898, respectively) were independent predictors of reclassification. CONCLUSIONS: Disease reclassification increased according to the PI-RADS score increase, at confirmatory or follow-up biopsy. However, a no-negligible rate of reclassification was found also in cases of mpMRI (-). The combination of mpMRI and clinicopathological variables still represents the most accurate approach to pts on active surveillance. CI - (c) 2020 Asian Pacific Prostate Society. Published by Elsevier B.V. FAU - Roscigno, Marco AU - Roscigno M AD - Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - Stabile, Armando AU - Stabile A AD - Department of Urology and Division of Experimental Oncology, URI, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Lughezzani, Giovanni AU - Lughezzani G AD - Department of Urology, Istituto Clinico Humanitas IRCCS-Clinical and Research Hospital, Rozzano, Italy. FAU - Pepe, Pietro AU - Pepe P AD - Urology Unit, Cannizzaro Hospital, Catania, Italy. FAU - Dell'Atti, Lucio AU - Dell'Atti L AD - Department of Urology, University Hospital "Ospedali Riuniti" and Polythecnic University of Marche Region, Ancona, Italy. FAU - Naselli, Angelo AU - Naselli A AD - Urology Department, Ospedale San Giuseppe, Gruppo Multimedica, Milan, Italy. FAU - Naspro, Richard AU - Naspro R AD - Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - Nicolai, Maria AU - Nicolai M AD - Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - La Croce, Giovanni AU - La Croce G AD - Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - Muhannad, Aljoulani AU - Muhannad A AD - Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - Perugini, Giovanna AU - Perugini G AD - Department of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - Guazzoni, Giorgio AU - Guazzoni G AD - Department of Urology, Istituto Clinico Humanitas IRCCS-Clinical and Research Hospital, Rozzano, Italy. AD - Department of Biomedical Science, Humanitas University, Milan, Rozzano, Italy. FAU - Montorsi, Francesco AU - Montorsi F AD - Department of Urology and Division of Experimental Oncology, URI, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Balzarini, Luca AU - Balzarini L AD - Dept. of Radiology, Humanitas Clinical and Research Center, Humanitas University, Rozzano, Italy. FAU - Sironi, Sandro AU - Sironi S AD - Department of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy. AD - University of Milano-Bicocca, School of Medicine and Surgery, Monza, Italy. FAU - Da Pozzo, Luigi F AU - Da Pozzo LF AD - Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy. AD - University of Milano-Bicocca, School of Medicine and Surgery, Monza, Italy. LA - eng PT - Journal Article DEP - 20200528 PL - Korea (South) TA - Prostate Int JT - Prostate international JID - 101605566 PMC - PMC7767935 OTO - NOTNLM OT - Active surveillance OT - MRI-TRUS fusion OT - Magnetic resonance imaging OT - Prostate biopsy OT - Prostate cancer COIS- All authors have no conflict of interest to declare. EDAT- 2021/01/12 06:00 MHDA- 2021/01/12 06:01 PMCR- 2020/05/28 CRDT- 2021/01/11 05:41 PHST- 2020/04/10 00:00 [received] PHST- 2020/04/25 00:00 [revised] PHST- 2020/05/14 00:00 [accepted] PHST- 2021/01/11 05:41 [entrez] PHST- 2021/01/12 06:00 [pubmed] PHST- 2021/01/12 06:01 [medline] PHST- 2020/05/28 00:00 [pmc-release] AID - S2287-8882(20)30031-3 [pii] AID - 10.1016/j.prnil.2020.05.003 [doi] PST - ppublish SO - Prostate Int. 2020 Dec;8(4):167-172. doi: 10.1016/j.prnil.2020.05.003. Epub 2020 May 28.