PMID- 33426876
OWN - NLM
STAT- MEDLINE
DCOM- 20210406
LR  - 20210406
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 69
IP  - 2
DP  - 2021 Jan 20
TI  - Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis 
      Acylphloroglucinol Meroterpenoids from Hypericum bellum Flowers.
PG  - 646-654
LID - 10.1021/acs.jafc.0c05417 [doi]
AB  - In this work, 26 methylated acylphloroglucinol meroterpenoids with diverse 
      skeletons, including 18 new ones (bellumones A-R, 1-18), were identified from the 
      flowers of Hypericum bellum. Their structures including absolute configurations 
      were elucidated by detailed spectroscopic data, calculated electronic circular 
      dichroism (ECD), and X-ray diffraction (XRD). Through methylation at C-5, 
      prenylation with different chain lengths of the acylphloroglucinol-derived core, 
      along with different types of secondary cyclization, type A bicyclic 
      polyprenylated acylphloroglucinols (BPAPs) (1-5 and 19-24) and dearomatized 
      isoprenylated acylphloroglucinols (DIAPs) (6-18 and 25-26) were obtained. The 
      significant results of anti-inflammatory, antioxidant, and anti-nonalcoholic 
      steatohepatitis (anti-NASH) activities suggest its usefulness in daily health 
      care.
FAU - Zhou, Xin
AU  - Zhou X
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Xu, Wenjun
AU  - Xu W
AUID- ORCID: 0000-0003-2567-969X
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Li, Yiran
AU  - Li Y
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Zhang, Meihui
AU  - Zhang M
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Tang, Pengfei
AU  - Tang P
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Lu, Weijia
AU  - Lu W
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Li, Qiji
AU  - Li Q
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Zhang, Hao
AU  - Zhang H
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Luo, Jun
AU  - Luo J
AUID- ORCID: 0000-0002-7892-011X
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
FAU - Kong, Lingyi
AU  - Kong L
AUID- ORCID: 0000-0001-9712-2618
AD  - State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive 
      Natural Product Research, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing 210009, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20210111
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Terpenes)
RN  - DHD7FFG6YS (Phloroglucinol)
SB  - IM
MH  - Anti-Inflammatory Agents/*chemistry/isolation & purification/pharmacology
MH  - Antioxidants/*chemistry/isolation & purification/pharmacology
MH  - Flowers/chemistry
MH  - Humans
MH  - Hypericum/*chemistry
MH  - Molecular Structure
MH  - Non-alcoholic Fatty Liver Disease/drug therapy
MH  - Phloroglucinol/*chemistry/isolation & purification/pharmacology
MH  - Terpenes/chemistry/isolation & purification/*pharmacology
OTO - NOTNLM
OT  - Hypericum bellum
OT  - acylphloroglucinol meroterpenoids
OT  - anti-NASH activity
OT  - anti-inflammatory activity
OT  - antioxidant activity
EDAT- 2021/01/12 06:00
MHDA- 2021/04/07 06:00
CRDT- 2021/01/11 08:40
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2021/01/11 08:40 [entrez]
AID - 10.1021/acs.jafc.0c05417 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2021 Jan 20;69(2):646-654. doi: 10.1021/acs.jafc.0c05417. Epub 
      2021 Jan 11.