PMID- 33426938
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20211224
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 55
IP  - 3
DP  - 2021 Jun
TI  - Clinical outcome of cardiac resynchronization therapy in patients randomized to 
      an active fixation bipolar left ventricular lead versus a passive quadripolar 
      lead.
PG  - 153-159
LID - 10.1080/14017431.2020.1869299 [doi]
AB  - Objectives: To compare the clinical outcome of cardiac resynchronization therapy 
      (CRT) in patients receiving a bipolar left ventricular (LV) lead with a side 
      helix for active fixation to the outcome in patients receiving a quadripolar 
      passive fixation LV lead.Design: Sixty-two patients (mean age 72 +/- 11 years) were 
      blindly and randomly assigned to the active fixation bipolar lead group (n = 31) 
      or to the quadripolar lead group (n= 31). The LV leads were targeted to the basal 
      LV segment in a vein concordant to the LV segment with the latest mechanical 
      contraction chosen on the basis of preoperative radial strain (RS) 
      echocardiography.Results: At the 6-month follow-up (FU), the reduction in LV 
      end-systolic volume and LV reverse remodelling responder rate, defined as LV 
      end-systolic volume reduction >15%, was 77% in the active fixation group and 83% 
      in the quadripolar group, which was not significantly different. At the 12-month 
      FU, the LV ejection fraction (LVEF) did not differ between the groups. There were 
      no significant differences between the two groups in changes in New York Heart 
      Association (NYHA) functional class or Minnesota Living with Heart Failure 
      Questionnaire score. The occurrence of phrenic nerve stimulation (PNS) was 19% in 
      the active fixation group versus 10% in the quadripolar group (p=.30), and all 
      cases were resolved by reprogramming the device. All patients were alive at the 
      12-month FU. There was no device infection.Conclusions: There were no significant 
      differences between the active fixation group of patients and the quadripolar 
      group of patients concerning improvement in echocardiographic parameters or 
      clinical symptoms.ClinicalTrials.gov number, NCT04632472.
FAU - Keilegavlen, Havard
AU  - Keilegavlen H
AUID- ORCID: 0000-0002-8190-9835
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
FAU - Schuster, Peter
AU  - Schuster P
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
FAU - Hovstad, Thomas
AU  - Hovstad T
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
FAU - Faerestrand, Svein
AU  - Faerestrand S
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
LA  - eng
SI  - ClinicalTrials.gov/NCT04632472
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210110
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiac Resynchronization Therapy/methods
MH  - Humans
MH  - Middle Aged
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - active fixation
OT  - heart failure
OT  - lead dislodgement
OT  - left ventricular lead placement
EDAT- 2021/01/12 06:00
MHDA- 2021/12/25 06:00
CRDT- 2021/01/11 08:40
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/01/11 08:40 [entrez]
AID - 10.1080/14017431.2020.1869299 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2021 Jun;55(3):153-159. doi: 10.1080/14017431.2020.1869299. 
      Epub 2021 Jan 10.