PMID- 33427278
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20210401
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 9
IP  - 4
DP  - 2021 Jan 28
TI  - Tannic acid/Mg(2+)-based versatile coating to manipulate the 
      osteoimmunomodulation of implants.
PG  - 1096-1106
LID - 10.1039/d0tb01577f [doi]
AB  - Instead of directly stimulating osteogenesis, endowing an implant surface with a 
      favourable osteoimmunomodulatory (OIM) function has emerged as a new effective 
      strategy to enhance osteointegration. Though metal-phenolic coatings have 
      demonstrated to possess an immunomodulatory function, their potential application 
      in manipulating an osteoimmune response has not been well explored. Herein, in 
      order to develop a simple, rapid and universal coating method to impart excellent 
      OIM to hard tissue implants, tannic acid (TA) and Mg(2+) were selected to form a 
      coating on Ti plate based on metal-phenolic chemistry. Besides its virtues of 
      simplicity, ultrafastness, low-cost, and versatility, another merit for the 
      coating method is that it can easily combine the unique functions of metal ions 
      and phenolic ligands. The chelated Mg(2+) can not only activate macrophage 
      polarization towards the anti-inflammatory phenotype but also directly stimulate 
      the osteogenic differentiation of bone marrow-derived stem cells (BMSCs). TA 
      motifs rendered the coating with an excellent reactive oxygen species (ROS) 
      scavenging capacity. TA and Mg(2+) showed synergistic effects on regulating 
      macrophage biological behaviour, suppressing its polarization towards the M1 
      phenotype, and promoting its polarization towards the M2 phenotype. In vivo 
      histological analysis also demonstrated that the TA/Mg(2+) coating could 
      effectively inhibit the host response. Finally, the formed osteoimmune 
      environment obviously enhanced the osteogenic differentiation of BMSCs. The above 
      results demonstrated that the designed TA/Mg(2+) coating not only possessed the 
      function of directly stimulating osteogenesis but also the function of 
      manipulating OIM to a desired one. Hence, it has great potential to be applied on 
      advanced hard tissue implants to enhance osteointegration.
FAU - He, Min
AU  - He M
AD  - Engineering Research Center of Oral Translational Medicine, Ministry of 
      Education, West China Hospital of Stomatology, Sichuan University, Chengdu, 
      Sichuan 610041, China. drtwd@sina.com.
FAU - Gao, Xinhui
AU  - Gao X
FAU - Fan, Yadi
AU  - Fan Y
FAU - Xie, Li
AU  - Xie L
FAU - Yang, Mo
AU  - Yang M
FAU - Tian, Weidong
AU  - Tian W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210111
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Tannins)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Coated Materials, Biocompatible/chemical synthesis/chemistry/*pharmacology
MH  - Immunomodulation/*drug effects
MH  - Magnesium/chemistry/*pharmacology
MH  - Mice
MH  - Osteogenesis/*drug effects
MH  - Particle Size
MH  - *Prostheses and Implants
MH  - RAW 264.7 Cells
MH  - Surface Properties
MH  - Tannins/chemistry/*pharmacology
EDAT- 2021/01/12 06:00
MHDA- 2021/04/02 06:00
CRDT- 2021/01/11 08:43
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2021/01/11 08:43 [entrez]
AID - 10.1039/d0tb01577f [doi]
PST - ppublish
SO  - J Mater Chem B. 2021 Jan 28;9(4):1096-1106. doi: 10.1039/d0tb01577f. Epub 2021 
      Jan 11.