PMID- 33429184
OWN - NLM
STAT- MEDLINE
DCOM- 20210909
LR  - 20210909
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 42
IP  - 2
DP  - 2021 Mar-Apr
TI  - High level of IgE in acute low-tone sensorineural hearing loss: A predictor for 
      recurrence and Meniere Disease transformation.
PG  - 102856
LID - S0196-0709(20)30550-0 [pii]
LID - 10.1016/j.amjoto.2020.102856 [doi]
AB  - BACKGROUND: Autoimmunity may play an important role in sudden onset sensorineural 
      hearing loss. However, little is known about the relationship between 
      immunoglobulin E (IgE) and acute low-tone sensorinerual hearing loss (ALHL). 
      OBJECTIVES: To investigate the relationship between IgE level and endolymphatic 
      hydrops and outcomes of ALHL. METHODS: A total of 242 subjects with sudden onset 
      hearing loss, including 115 with ALHL and 127 with idiopathic sudden 
      sensorineural hearing loss (ISSHL), were included in this study. Peripheral 
      venous blood samples of 242 subjects were collected for detection. Clinical data, 
      IgE level, and distribution of allergens were compared between the ALHL and ISSHL 
      groups. The ALHL group received an electrocochleogram (ECochG) test and a 
      follow-up in the outpatient unit or by telephone to evaluate outcomes. RESULTS: 
      Compared to the values in the ISSHL group, a significantly younger onset age 
      (42.30+/-14.33 years old), higher female onset proportion (72/115, 62.61%), 
      increased total IgE level (median: 66.47, interquartile range: 24.56, 180.96, 
      IU/mL) and specific IgE level (median: 9.42, interquartile range: 1.42, 
      22.23 IU/mL) were noted in the ALHL group. A clear difference in allergen 
      distribution was noted between the ALHL and ISSHL groups (p=.001). Total IgE and 
      specific IgE levels were factors that contributed to the SP/AP ratio in the 
      electrocochleogram (ECochG) (R(2)=0.413) in ALHL group. Finally, during the 
      follow-up (17.61+/-3.46 months) for the ALHL group, 37 subjects recurred, and 17 
      subjects developed Meniere Disease. In the ROC curve for ALHL recurrence, the 
      area under the curve (AUC) of total IgE was 0.709 and that of specific IgE was 
      0.679. For MD transformation, the AUC of total IgE was 0.736 and that of specific 
      IgE was 0.716. CONCLUSIONS: High IgE levels correlated with an enhanced SP/AP 
      ratio in ALHL. High IgE levels could be used as a predictor of ALHL recurrence 
      and MD transformation.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Ma, Yu
AU  - Ma Y
AD  - Department of Otolaryngology, Fourth Affiliated Hospital of China Medical 
      University.
FAU - Sun, Qian
AU  - Sun Q
AD  - Department of Otolaryngology, Fourth Affiliated Hospital of China Medical 
      University.
FAU - Zhang, Kaili
AU  - Zhang K
AD  - Department of Otolaryngology, Fourth Affiliated Hospital of China Medical 
      University.
FAU - Bai, Letian
AU  - Bai L
AD  - Department of Otolaryngology, Fourth Affiliated Hospital of China Medical 
      University.
FAU - Du, Li
AU  - Du L
AD  - Department of Otolaryngology, Fourth Affiliated Hospital of China Medical 
      University. Electronic address: duli_ent@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210104
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Biomarkers)
RN  - 0 (Biosimilar Pharmaceuticals)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Age of Onset
MH  - Audiometry, Evoked Response
MH  - *Autoimmunity
MH  - Biomarkers/blood
MH  - Biosimilar Pharmaceuticals
MH  - Endolymphatic Hydrops/immunology
MH  - Female
MH  - Hearing Loss, Sensorineural/*complications/diagnosis/epidemiology/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Meniere Disease/diagnosis/*epidemiology/*etiology
MH  - Middle Aged
MH  - Recurrence
MH  - Sex Factors
MH  - Time Factors
OTO - NOTNLM
OT  - Acute low-tone sensorineural hearing loss
OT  - Allergen
OT  - Electrocochleogram
OT  - Idiopathic sudden sensorineural hearing loss
OT  - IgE
OT  - Meniere Disease
OT  - Specific IgE
EDAT- 2021/01/12 06:00
MHDA- 2021/09/10 06:00
CRDT- 2021/01/11 20:12
PHST- 2020/09/15 00:00 [received]
PHST- 2020/11/26 00:00 [revised]
PHST- 2020/12/22 00:00 [accepted]
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/09/10 06:00 [medline]
PHST- 2021/01/11 20:12 [entrez]
AID - S0196-0709(20)30550-0 [pii]
AID - 10.1016/j.amjoto.2020.102856 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2021 Mar-Apr;42(2):102856. doi: 10.1016/j.amjoto.2020.102856. 
      Epub 2021 Jan 4.