PMID- 33429284
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 199
DP  - 2021 Mar
TI  - Polymeric non-spherical coarse microparticles fabricated by double 
      emulsion-solvent evaporation for simvastatin delivery.
PG  - 111560
LID - S0927-7765(21)00004-7 [pii]
LID - 10.1016/j.colsurfb.2021.111560 [doi]
AB  - Polymeric particles with non-spherical shape or coarse surface have distinct 
      advantages for drug delivery, tissue regeneration and immunomodulation 
      respectively, but it is not easy to control polymeric microparticles in required 
      geometry and surface texture simultaneously. In this study, polymeric 
      non-spherical microparticles with coarse surface were successfully prepared by 
      double emulsion-solvent evaporation technique in the presence of ammonium 
      bicarbonate and the formation mechanism was proposed. In addition, simvastatin 
      was encapsulated in poly[lactic-co-(glycolic acid)] (PLGA) non-spherical 
      microparticles with coarse surface by the same technique and the release kinetics 
      in vitro was fitted as well, which not only enrich the encapsulation techniques 
      of liposoluble drugs in polymeric non-spherical carriers but also envision the 
      potential application for alveolar ridge preservation with local delivery of 
      simvastatin.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zhang, Junjiang
AU  - Zhang J
AD  - Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, 
      China.
FAU - Wang, Jianghong
AU  - Wang J
AD  - Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, 
      China.
FAU - Qiao, Feng
AU  - Qiao F
AD  - Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, 
      China.
FAU - Liu, Yaoshan
AU  - Liu Y
AD  - Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, 
      China.
FAU - Zhou, Yiwen
AU  - Zhou Y
AD  - Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, 
      China.
FAU - Li, Min
AU  - Li M
AD  - Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Tianjin Key 
      Laboratory of Biomedical Materials, Tianjin, 300192, China.
FAU - Ai, Mingyue
AU  - Ai M
AD  - Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Tianjin Key 
      Laboratory of Biomedical Materials, Tianjin, 300192, China.
FAU - Yang, Yuzhou
AU  - Yang Y
AD  - Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Tianjin Key 
      Laboratory of Biomedical Materials, Tianjin, 300192, China.
FAU - Sui, Lei
AU  - Sui L
AD  - Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, 
      China. Electronic address: suilei@tmu.edu.cn.
FAU - Zhou, Zhimin
AU  - Zhou Z
AD  - Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Tianjin Key 
      Laboratory of Biomedical Materials, Tianjin, 300192, China. Electronic address: 
      zhouzm@bme.cams.cn.
LA  - eng
PT  - Journal Article
DEP - 20210106
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsions)
RN  - 0 (Solvents)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Drug Carriers
MH  - Emulsions
MH  - *Lactic Acid
MH  - Microspheres
MH  - Particle Size
MH  - *Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Simvastatin
MH  - Solvents
OTO - NOTNLM
OT  - Alveolar ridge preservation
OT  - Double emulsion-solvent evaporation
OT  - Non-spherical particles
OT  - PLGA
OT  - Simvastatin delivery
EDAT- 2021/01/12 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/01/11 20:15
PHST- 2020/11/08 00:00 [received]
PHST- 2020/12/18 00:00 [revised]
PHST- 2021/01/03 00:00 [accepted]
PHST- 2021/01/12 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/11 20:15 [entrez]
AID - S0927-7765(21)00004-7 [pii]
AID - 10.1016/j.colsurfb.2021.111560 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2021 Mar;199:111560. doi: 
      10.1016/j.colsurfb.2021.111560. Epub 2021 Jan 6.