PMID- 33431266
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20210729
IS  - 0035-3787 (Print)
IS  - 0035-3787 (Linking)
VI  - 177
IP  - 6
DP  - 2021 Jun
TI  - Seizure incidence among neuromyelitis optica spectrum disorder patients.
PG  - 655-659
LID - S0035-3787(20)30736-0 [pii]
LID - 10.1016/j.neurol.2020.08.011 [doi]
AB  - BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of 
      neuroinflammatory diseases, which mainly affect the optic nerve and spinal cord. 
      NMOSD is an astrocytic channelopathy involving the aquaporin-4 (AQP4) water 
      channels in the central nervous system. Patients can present with seizure attacks 
      as a first manifestation or relapse. However, compared with multiple sclerosis 
      (MS) or myelin oligodendrocyte glycoprotein encephalomyelitis (MOG-EM), seizure 
      attacks are less frequent in NMOSD. METHODS: In this study, we aimed to find out 
      the incidence of seizure attacks during the disease course of 137 NMOSD patients 
      who were registered in our centre from January 2011 till January 2020. 
      Furthermore, we reviewed the literature for NMOSD cases with seizure attacks 
      during their follow-up, in order to investigate the reason for this low incidence 
      of seizures. RESULTS: Only one of our patients (0.72%) experienced an episode of 
      generalised tonic-clonic seizure during his follow-up. CONCLUSION: Reviewing the 
      literature revealed that although seizures are rare in NMOSD, AQP4 disruption 
      possibly increases the risk of seizure attacks. We therefore concluded that the 
      role of AQP4 in seizures is controversial and needs more investigation.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Etemadifar, M
AU  - Etemadifar M
AD  - Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Sabeti, F
AU  - Sabeti F
AD  - School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 
      Electronic address: sabetifateme@yahoo.com.
FAU - Khorvash, R
AU  - Khorvash R
AD  - School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Mirbagheri, M
AU  - Mirbagheri M
AD  - School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Nouri, H
AU  - Nouri H
AD  - School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Salari, M
AU  - Salari M
AD  - Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210108
PL  - France
TA  - Rev Neurol (Paris)
JT  - Revue neurologique
JID - 2984779R
RN  - 0 (Autoantibodies)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Autoantibodies
MH  - Humans
MH  - Incidence
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - *Neuromyelitis Optica/complications
MH  - *Seizures/etiology
OTO - NOTNLM
OT  - Aquaporin 4
OT  - Astrocyte
OT  - Neuromyelitis optica
OT  - Seizure
EDAT- 2021/01/13 06:00
MHDA- 2021/07/30 06:00
CRDT- 2021/01/12 05:48
PHST- 2020/03/27 00:00 [received]
PHST- 2020/07/29 00:00 [revised]
PHST- 2020/08/28 00:00 [accepted]
PHST- 2021/01/13 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2021/01/12 05:48 [entrez]
AID - S0035-3787(20)30736-0 [pii]
AID - 10.1016/j.neurol.2020.08.011 [doi]
PST - ppublish
SO  - Rev Neurol (Paris). 2021 Jun;177(6):655-659. doi: 10.1016/j.neurol.2020.08.011. 
      Epub 2021 Jan 8.