PMID- 33431966
OWN - NLM
STAT- MEDLINE
DCOM- 20210730
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 11
TI  - Opioid use may be associated with postoperative complications in myotonic 
      dystrophy type 1 with high-grade muscular impairment.
PG  - 8
LID - 10.1038/s41598-020-76217-9 [doi]
LID - 8
AB  - Individuals with myotonic dystrophy type 1 (DM1) reportedly have a higher risk of 
      postoperative complications than those without DM1; however, factors related to 
      perioperative complications in DM1 patients remain unclear. We aimed to identify 
      the risk factors that may be associated with postoperative complications in DM1 
      patients. We reviewed medical records of 256 patients with DM1 from 1998 to 2018, 
      among whom 42 (16.4%) had previously undergone 51 surgeries under general and 
      regional anaesthesia. Among the 42 patients, 11 (21.5%) had 13 postoperative 
      complications including respiratory complications, sustained hypotension, wound 
      infection and dehiscence, artery thrombosis and occlusion, and delayed recovery 
      from anaesthesia. There were significant inter-group differences between the 
      non-complicated and complicated groups considering the following parameters: 
      high-grade (>/= 3) muscular impairment rating scale (MIRS), extubation time, 
      postoperative opioid use, and hospital length of stay. Furthermore, univariate 
      analysis revealed that an MIRS score >/= 3 (odds ratio [OR] 9.346, confidence 
      interval [CI] 1.761-49.595, p = 0.009) and postoperative opioid use (OR 8.000, CI 
      1.772-36.127, p = 0.007) were the only statistically significant factors. 
      Therefore, clinicians should be cautious in administering opioids, particularly 
      in patients with a high-grade MIRS score during the perioperative period.
FAU - Kim, Chan-Sik
AU  - Kim CS
AD  - Department of Anesthesiology and Pain Medicine, Asan Medical Center, University 
      of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, 
      Republic of Korea.
FAU - Park, Jin-Mo
AU  - Park JM
AD  - Department of Neurology, Dongguk University College of Medicine, Gyeongju, 
      Republic of Korea.
FAU - Park, Donghwi
AU  - Park D
AD  - Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, 
      University of Ulsan College of Medicine, Ulsan, Republic of Korea.
FAU - Kim, Doo-Hwan
AU  - Kim DH
AD  - Department of Anesthesiology and Pain Medicine, Asan Medical Center, University 
      of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, 
      Republic of Korea. knaaddict@gmail.com.
FAU - Park, Jin-Sung
AU  - Park JS
AD  - Department of Neurology, School of Medicine, Kyungpook National University, 
      Kyungpook National University Chilgok Hospital, 807 Hoguk-ro, Buk-gu, Daegu, 
      41404, Republic of Korea. jinforeva@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210111
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analgesics, Opioid/*adverse effects
MH  - Anesthetics/adverse effects/therapeutic use
MH  - Asian People
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Myotonic Dystrophy/complications/*physiopathology
MH  - Pain, Postoperative/drug therapy
MH  - Postoperative Complications/*etiology
MH  - Respiratory Insufficiency/epidemiology/etiology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC7801477
COIS- The authors declare no competing interests.
EDAT- 2021/01/13 06:00
MHDA- 2021/07/31 06:00
PMCR- 2021/01/11
CRDT- 2021/01/12 06:04
PHST- 2020/05/11 00:00 [received]
PHST- 2020/10/22 00:00 [accepted]
PHST- 2021/01/12 06:04 [entrez]
PHST- 2021/01/13 06:00 [pubmed]
PHST- 2021/07/31 06:00 [medline]
PHST- 2021/01/11 00:00 [pmc-release]
AID - 10.1038/s41598-020-76217-9 [pii]
AID - 76217 [pii]
AID - 10.1038/s41598-020-76217-9 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jan 11;11(1):8. doi: 10.1038/s41598-020-76217-9.