PMID- 33432875
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20220428
IS  - 1784-973X (Electronic)
IS  - 0001-5385 (Linking)
VI  - 76
IP  - 9
DP  - 2021 Nov
TI  - Comparison of de novo versus upgrade cardiac resynchronisation therapy on 
      clinical effect and long-term outcome.
PG  - 993-1000
LID - 10.1080/00015385.2020.1867387 [doi]
AB  - BACKGROUND: The benefit of de novo cardiac resynchronisation therapy (CRT) 
      implantation in selected patients with heart failure is well known. The number of 
      upgrade procedures is increasing but data on clinical response and outcome are 
      less well documented as compared to de novo implantation. OBJECTIVES: To 
      investigate the efficacy and outcome of CRT upgrade procedures in patients with 
      existing cardiac implantable electronic devices (CIEDs). METHODS: Baseline 
      characteristics, change in New York Heart Association (NYHA) functional class, 
      echocardiographic parameters, life-threatening ventricular tachyarrhythmias, 
      all-cause mortality and mode of death were evaluated in CRT patients with the 
      comparison between de novo and upgrade CRT procedures. RESULTS: About 410 
      patients (CRT upgrade/de novo CRT, n = 97/313) were followed for 
      63.5 +/- 38.1 months. Upgrade patients were older (75.5 +/- 8.1 vs 69.9 +/- 10.7 years; 
      p < 0.001), had more often an ischaemic cause of heart failure (58.8% vs 45.4%; 
      p = 0.021), a higher NYHA functional class (p = 0.004) and a higher comorbidity 
      burden. Improvement in left ventricular ejection fraction (LVEF) was higher in 
      the de novo CRT group (8.4 +/- 9.9 vs 11.0 +/- 10.3%; p = 0.035). Clinical response 
      was similar between both groups (60.5 vs 62.5%; p = 0.793), as was mortality at 1 
      year (8.2 vs 5.8%; p = 0.351) and at last follow-up (33.0 vs 28.8%; p = 0.447). 
      The proportion of cardiovascular related deaths was similar between both groups 
      (46.9% vs 38.9%; p = 0.531). CONCLUSIONS: Patients with CRT upgrade procedures 
      have similar symptomatic improvements, as well as 1 year and long-term outcome as 
      compared to patients with de novo CRT implantation.
FAU - Stassen, Jan
AU  - Stassen J
AUID- ORCID: 0000-0001-9745-5498
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Scherrenberg, Martijn
AU  - Scherrenberg M
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
AD  - Faculty of Medicine and Life Sciences, UHasselt - Hasselt University, Agoralaan, 
      Belgium.
FAU - Dilling-Boer, Dagmara
AU  - Dilling-Boer D
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Vijgen, Johan
AU  - Vijgen J
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Koopman, Pieter
AU  - Koopman P
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Schurmans, Joris
AU  - Schurmans J
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Herbots, Lieven
AU  - Herbots L
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Verwerft, Jan
AU  - Verwerft J
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Schroyens, Matthew
AU  - Schroyens M
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
FAU - Timmermans, Philippe
AU  - Timmermans P
AD  - Heart Centre, Jessa Hospital Hasselt, Hasselt, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20210112
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - *Heart Failure/therapy
MH  - Humans
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac resynchronisation therapy
OT  - morbidity
OT  - mortality
OT  - upgrade
EDAT- 2021/01/13 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/01/12 08:37
PHST- 2021/01/13 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/01/12 08:37 [entrez]
AID - 10.1080/00015385.2020.1867387 [doi]
PST - ppublish
SO  - Acta Cardiol. 2021 Nov;76(9):993-1000. doi: 10.1080/00015385.2020.1867387. Epub 
      2021 Jan 12.