PMID- 33433961
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 10
IP  - 8
DP  - 2021 Apr
TI  - Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs 
      for Lung Targeting, Esterase Triggering, and Synergy Therapy.
PG  - e2001803
LID - 10.1002/adhm.202001803 [doi]
AB  - Most anticancer drugs, particularly paclitaxel (PTX), are suffering the 
      challenges of cancer chemotherapy due to their poor water-solubility, high 
      toxicity under effective therapeutic dosages, and multi-drug resistance. 
      Currently, nanoscale drug delivery systems (DDSs) represent an efficient platform 
      to overcome the above challenges. However, those DDSs generally need a careful 
      design of conjugation, complexation, or co-self-assembly. Herein, a facile 
      out-of-the-box nanocapsule is developed not only to be easily packed with 
      on-demand hydrophobic anticancer drugs (up to 76% of loading efficiency for PTX), 
      but also to be loaded with other concomitant drugs for synergy therapy 
      (Itraconazole (ITA) here as P-glycoprotein inhibitor for drug resistance and 
      antiangiogenic agent for combination therapy with PTX). Three kinds of 
      biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) derivatives usually 
      as cross-linking agents are selected and successfully constructed adequate 
      nanocapsules with single monomer as shell materials. More importantly, 
      as-prepared nanocapsules have abilities of esterase triggering and lung 
      targeting. Both in vitro and in vivo studies showed that the drug-loaded 
      nanocapsules can effectively inhibit tumor growth and vascular proliferation in 
      PTX-resistant tumor models without apparent systemic toxicity. The above results 
      demonstrate that the nanocapsule system provides an effective and universal 
      strategy for lung targeting, esterase triggering, and synergy therapy.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Zhao, Di
AU  - Zhao D
AUID- ORCID: 0000-0002-0774-9861
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
AD  - School of Perfume and Aroma Technology, Shanghai Institute of Technology, 
      Shanghai, 201418, P. R. China.
FAU - Jiang, Kai
AU  - Jiang K
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
FAU - Wang, Yuqi
AU  - Wang Y
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
FAU - Cheng, Jin
AU  - Cheng J
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
FAU - Mo, Fangli
AU  - Mo F
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
FAU - Luo, Tao
AU  - Luo T
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
FAU - Guo, Yuanyuan
AU  - Guo Y
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
FAU - Zhang, Chuan
AU  - Zhang C
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules, State Key Laboratory of Metal Matrix Composites, 
      Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
FAU - Song, Jie
AU  - Song J
AUID- ORCID: 0000-0002-4711-6014
AD  - Institute of Nano Biomedicine and Engineering, Department of Instrument Science 
      and Engineering, School of Electronic Information and Electrical Engineering, 
      Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
AD  - Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, The 
      Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, 
      Zhejiang, 310022, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210112
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Nanocapsules)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - EC 3.1.- (Esterases)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - *Antineoplastic Agents
MH  - Cell Line, Tumor
MH  - Drug Delivery Systems
MH  - Esterases
MH  - Lung
MH  - *Nanocapsules
MH  - Paclitaxel
MH  - Polyethylene Glycols
OTO - NOTNLM
OT  - controllable esterase response
OT  - high loading efficiency
OT  - lung targeting
OT  - multi-drug resistance
OT  - universal drug encapsulation
EDAT- 2021/01/13 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/01/12 12:26
PHST- 2020/12/13 00:00 [revised]
PHST- 2020/10/13 00:00 [received]
PHST- 2021/01/13 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/01/12 12:26 [entrez]
AID - 10.1002/adhm.202001803 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2021 Apr;10(8):e2001803. doi: 10.1002/adhm.202001803. Epub 
      2021 Jan 12.