PMID- 33434615
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20221221
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 92
DP  - 2021 May
TI  - Randomized controlled trials for alcohol use disorder during the COVID-19 
      pandemic.
PG  - 21-24
LID - S0741-8329(21)00001-X [pii]
LID - 10.1016/j.alcohol.2021.01.001 [doi]
AB  - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) altered 
      the logistics of ongoing randomized controlled trials (RCTs). The need to reduce 
      in-person research and clinical activities, however, presented an additional 
      level of complexity in order to continue conducting RCTs that focused on the 
      development of medications for Alcohol Use Disorder (AUD). The visits required a 
      systematic objective evaluation from the physician and mental health professional 
      and clinical staff, as many of the safety and efficacy assessments are 
      self-reported. The following commentary addresses the successes and limitations 
      our RCTs encountered during the coronavirus (COVID-19) pandemic.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Brown, Zoe E
AU  - Brown ZE
AD  - Center for Alcohol and Addiction Studies, Brown University Providence, RI, United 
      States.
FAU - Portis, Samantha M
AU  - Portis SM
AD  - Center for Alcohol and Addiction Studies, Brown University Providence, RI, United 
      States; Department of Behavioral and Social Sciences, School of Public Health, 
      Brown University Providence, RI, United States.
FAU - Fleig, Carline L
AU  - Fleig CL
AD  - Center for Alcohol and Addiction Studies, Brown University Providence, RI, United 
      States.
FAU - Vasaturo-Kolodner, Talia
AU  - Vasaturo-Kolodner T
AD  - Department of Neuroscience, Brown University, Providence, RI, United States.
FAU - Swift, Robert M
AU  - Swift RM
AD  - Center for Alcohol and Addiction Studies, Brown University Providence, RI, United 
      States; Department of Psychiatry and Human Behavior, Warren Alpert Medical 
      School, Brown University, Providence, RI, United States; Veterans Administration 
      Medical Center, Providence, RI, United States.
FAU - Haass-Koffler, Carolina L
AU  - Haass-Koffler CL
AD  - Center for Alcohol and Addiction Studies, Brown University Providence, RI, United 
      States; Department of Behavioral and Social Sciences, School of Public Health, 
      Brown University Providence, RI, United States; Department of Neuroscience, Brown 
      University, Providence, RI, United States; Department of Psychiatry and Human 
      Behavior, Warren Alpert Medical School, Brown University, Providence, RI, United 
      States. Electronic address: carolina_haass-koffler@brown.edu.
LA  - eng
GR  - R01 AA027760/AA/NIAAA NIH HHS/United States
GR  - R01 AA026589/AA/NIAAA NIH HHS/United States
GR  - K01 AA023867/AA/NIAAA NIH HHS/United States
GR  - P20 GM130414/GM/NIGMS NIH HHS/United States
GR  - R21 AA027614/AA/NIAAA NIH HHS/United States
GR  - T32 AA007459/AA/NIAAA NIH HHS/United States
PT  - Editorial
PT  - Research Support, N.I.H., Extramural
DEP - 20210109
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
SB  - IM
MH  - Alcoholism/*prevention & control
MH  - COVID-19/*epidemiology
MH  - Health Services Accessibility
MH  - Humans
MH  - Patient Selection
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Remote Consultation
MH  - Self Report
MH  - Substance Withdrawal Syndrome
PMC - PMC7832637
COIS- Declaration of competing interest The authors have declared that no conflict of 
      interest exists. There are no relationships between financial supporters or other 
      organizations and these authors that could have influenced the study and results.
EDAT- 2021/01/13 06:00
MHDA- 2021/04/20 06:00
PMCR- 2021/01/09
CRDT- 2021/01/12 20:08
PHST- 2020/12/16 00:00 [received]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/01/06 00:00 [accepted]
PHST- 2021/01/13 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2021/01/12 20:08 [entrez]
PHST- 2021/01/09 00:00 [pmc-release]
AID - S0741-8329(21)00001-X [pii]
AID - 10.1016/j.alcohol.2021.01.001 [doi]
PST - ppublish
SO  - Alcohol. 2021 May;92:21-24. doi: 10.1016/j.alcohol.2021.01.001. Epub 2021 Jan 9.