PMID- 33434998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210113
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 4
IP  - 8
DP  - 2018 Aug 13
TI  - Red Blood Cell-Shaped Microparticles with a Red Blood Cell Membrane Demonstrate 
      Prolonged Circulation Time in Blood.
PG  - 2729-2732
LID - 10.1021/acsbiomaterials.8b00197 [doi]
AB  - Prolonging the circulation time (CT) of microparticles (MPs) in the blood is key 
      for a successful microparticle-based medicinal approach to serve as drug delivery 
      systems (DDSs). Previously, we reported that MPs that mimic the shape of red 
      blood cells (RBCs) avoid accumulation in the spleen and lungs. We now describe 
      the effectiveness of mimicking not only the shape of RBCs but also their surface 
      structure for the prolongation of CT. RBC-shaped MPs (RBC-MPs) were 
      electrosprayed with cellulose and covered with a native RBC membrane (RBCM) 
      collected from mouse blood. Seven hours after intravenous injection, 
      approximately twice as many RBCM-covered RBC-MPs (RBC-MPs@RBCM) were present in 
      the blood of mice compared to unmodified RBC-MPs. Twenty-four hours 
      postinjection, the concentration of RBC-MPs@RBCM in the blood was 4 times higher. 
      These findings suggest that an RBCM covering the MPs contributed to significant 
      CT prolongation, which may positively impact their applications as DDSs.
FAU - Hayashi, Koichiro
AU  - Hayashi K
AUID- ORCID: 0000-0002-3147-5784
AD  - Division of Materials Research, Institute of Materials and Systems for 
      Sustainability, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
AD  - Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 
      Maidashi, Higashi-ku, Fukuoka 812-0044, Japan.
FAU - Yamada, Shota
AU  - Yamada S
AD  - Division of Materials Research, Institute of Materials and Systems for 
      Sustainability, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
FAU - Sakamoto, Wataru
AU  - Sakamoto W
AD  - Division of Materials Research, Institute of Materials and Systems for 
      Sustainability, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
FAU - Usugi, Eri
AU  - Usugi E
AD  - Oncologic Pathology Graduate School of Medicine, Mie University, 2-174 Edobashi, 
      Tsu 514-8507, Japan.
FAU - Watanabe, Masatoshi
AU  - Watanabe M
AD  - Oncologic Pathology Graduate School of Medicine, Mie University, 2-174 Edobashi, 
      Tsu 514-8507, Japan.
FAU - Yogo, Toshinobu
AU  - Yogo T
AD  - Division of Materials Research, Institute of Materials and Systems for 
      Sustainability, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180713
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - biodistribution
OT  - biomimetics
OT  - drug delivery
OT  - nanomedicine
OT  - smart materials
EDAT- 2018/08/13 00:00
MHDA- 2018/08/13 00:01
CRDT- 2021/01/13 01:00
PHST- 2021/01/13 01:00 [entrez]
PHST- 2018/08/13 00:00 [pubmed]
PHST- 2018/08/13 00:01 [medline]
AID - 10.1021/acsbiomaterials.8b00197 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2018 Aug 13;4(8):2729-2732. doi: 
      10.1021/acsbiomaterials.8b00197. Epub 2018 Jul 13.