PMID- 33435056
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210113
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 4
IP  - 9
DP  - 2018 Sep 10
TI  - Enhancing the Cell-Biological Performances of Hydroxyapatite Bioceramic by 
      Constructing Silicate-Containing Grain Boundary Phases via Sol Infiltration.
PG  - 3154-3162
LID - 10.1021/acsbiomaterials.8b00697 [doi]
AB  - Hydroxyapatite (HA) is well-known as one of the excellent bone repair 
      biomaterials because of its chemical similarity with biological apatite. However, 
      weak bioactivity obstructs its application. Although the bioactivity of HA 
      bioceramic could be enhanced by the incorporation of bioactive glass (BG), the 
      dramatic decrease of its mechanical property is consistently a disturbance to the 
      reliable efficacy of traditional modified HA bioceramic. In this study, HA 
      bioceramic was modified by infiltration of BG sol and formation of 
      silicate-containing grain boundary phases during subsequent sintering. The phase 
      compositions, microstructure, mechanical performance, in vitro degradation 
      behaviors, and osteogenesis of the bioceramic were investigated. The modified HA 
      bioceramic exhibited an interesting phenomenon in which the HA grains were 
      uniformly enveloped by the small silicate-containing grains in the boundaries of 
      HA grains. The microporosity of modified HA bioceramics was up to 25.27% +/- 0.01%, 
      much higher than that of unmodified HA bioceramic (1.74% +/- 0.27%). The 
      compressive strength of the modified HA bioceramic via BG sol infiltration was 
      much higher than that of the HA bioceramic modified by BG via mechanical blending 
      method, though slightly lower than that of the blank. Moreover, mouse bone 
      mesenchymal stem cells (mBMSCs) cultured on modified bioceramic displayed better 
      adhesion morphology and proliferation, and had an enhanced expression of 
      osteogenesis-related genes. This study offers a new strategy to improve the 
      bioactivity of HA bioceramic without obvious deterioration in mechanical 
      strength.
FAU - Xu, Yubin
AU  - Xu Y
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China.
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      Guangzhou 510006, China.
FAU - Lu, Teliang
AU  - Lu T
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China.
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      Guangzhou 510006, China.
FAU - He, Fupo
AU  - He F
AD  - School of Electromechanical Engineering, Guangdong University of Technology, 
      Guangzhou 510006, China.
FAU - Ma, Ning
AU  - Ma N
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China.
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      Guangzhou 510006, China.
FAU - Ye, Jiandong
AU  - Ye J
AUID- ORCID: 0000-0002-5366-2054
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China.
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      Guangzhou 510006, China.
FAU - Wu, Tingting
AU  - Wu T
AD  - Center of Joint Surgery and Sports Medicine, Institute of Orthopedic Diseases, 
      The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
LA  - eng
PT  - Journal Article
DEP - 20180823
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - grain boundary phase
OT  - hydroxyapatite
OT  - microporous
OT  - osteogenesis
OT  - silicate
EDAT- 2018/09/10 00:00
MHDA- 2018/09/10 00:01
CRDT- 2021/01/13 01:00
PHST- 2021/01/13 01:00 [entrez]
PHST- 2018/09/10 00:00 [pubmed]
PHST- 2018/09/10 00:01 [medline]
AID - 10.1021/acsbiomaterials.8b00697 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2018 Sep 10;4(9):3154-3162. doi: 
      10.1021/acsbiomaterials.8b00697. Epub 2018 Aug 23.