PMID- 33435282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210218
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 10
IP  - 1
DP  - 2021 Jan 9
TI  - Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug 
      Discovery.
LID - 10.3390/antiox10010081 [doi]
LID - 81
AB  - Type 2 diabetes mellitus (T2DM) is one of the largest public health problems 
      worldwide. Insulin resistance-related metabolic dysfunction and chronic 
      hyperglycemia result in devastating complications and poor prognosis. Even though 
      there are many conventional drugs such as metformin (MET), Thiazolidinediones 
      (TZDs), sulfonylureas (SUF), dipeptidyl peptidase 4 (DPP-4) inhibitors, glucagon 
      like peptide 1 (GLP-1) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, 
      side effects still exist. As numerous plant extracts with antidiabetic effects 
      have been widely reported, they have the potential to be a great therapeutic 
      agent for type 2 diabetes with less side effects. In this study, sixty-five 
      recent studies regarding plant extracts that alleviate type 2 diabetes were 
      reviewed. Plant extracts regulated blood glucose through the phosphoinositide 
      3-kinase (PI3K)/protein kinase B (Akt) pathway. The anti-inflammatory and 
      antioxidant properties of plant extracts suppressed c-Jun amino terminal kinase 
      (JNK) and nuclear factor kappa B (NF-kappaB) pathways, which induce insulin 
      resistance. Lipogenesis and fatty acid oxidation, which are also associated with 
      insulin resistance, are regulated by AMP-activated protein kinase (AMPK) 
      activation. This review focuses on discovering plant extracts that alleviate type 
      2 diabetes and exploring its therapeutic mechanisms.
FAU - Lee, Jinjoo
AU  - Lee J
AD  - College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
AD  - Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 
      02447, Korea.
FAU - Noh, Seungjin
AU  - Noh S
AD  - College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
FAU - Lim, Suhyun
AU  - Lim S
AD  - College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
FAU - Kim, Bonglee
AU  - Kim B
AUID- ORCID: 0000-0002-8678-156X
AD  - College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
AD  - Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 
      02447, Korea.
AD  - Korean Medicine-Based Drug Repositioning Cancer Research Center, College of 
      Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
LA  - eng
GR  - No. 2020R1A5A201941311/the National Research Foundation of Korea (NRF) grant 
      funded by the Korea government (MSIT)/
GR  - NRF-2020R1I1A2066868/Basic Science Research Program through the National Research 
      Foundation of Korea (NRF) funded by the Ministry of Education/
GR  - HF20C0116/a grant of the Korea Health Technology R&D Project through the Korea 
      Health Industry Development Institute (KHIDI), funded by the Ministry of Health & 
      Welfare, Republic of Korea/
GR  - HB20C0038/a grant of the Korea Health Technology R&D Project through the Korea 
      Health Industry Development Institute (KHIDI), funded by the Ministry of Health & 
      Welfare, Republic of Korea/
PT  - Journal Article
PT  - Review
DEP - 20210109
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7827314
OTO - NOTNLM
OT  - antioxidant
OT  - diabetes mellitus
OT  - glucose transport
OT  - inflammation
OT  - lipid metabolism
OT  - plant extracts
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/14 06:00
MHDA- 2021/01/14 06:01
PMCR- 2021/01/09
CRDT- 2021/01/13 01:01
PHST- 2020/12/05 00:00 [received]
PHST- 2021/01/04 00:00 [revised]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/01/13 01:01 [entrez]
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2021/01/14 06:01 [medline]
PHST- 2021/01/09 00:00 [pmc-release]
AID - antiox10010081 [pii]
AID - antioxidants-10-00081 [pii]
AID - 10.3390/antiox10010081 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2021 Jan 9;10(1):81. doi: 10.3390/antiox10010081.