PMID- 33435703
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20220428
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 31
IP  - 6
DP  - 2021 Nov
TI  - Diagnosis of optic nerve head drusen using enhanced depth imaging optical 
      coherence tomography.
PG  - 3476-3482
LID - 10.1177/1120672120986374 [doi]
AB  - PURPOSE: To evaluate the efficacy of Enhanced Depth Imaging Optical Coherence 
      Tomography (EDI-OCT) in differentiating between optic nerve head drusen (ONHD) 
      and optic disc oedema (ODE). METHODS: This was a cross-sectional study of 140 
      patients: 83 patients with ONHD (49 hidden and 34 visible), 20 patients with 
      pseudopapilloedema (without drusen), and 37 patients with ODE. EDI-OCT of the 
      optic nerve was performed, selecting one high-resolution line from the HD 5-line 
      raster protocol. Two observers blindly evaluated the presence of a hyporeflective 
      core surrounded by a hyperreflective margin or border. The sensitivity, 
      specificity, predictive values and posttest probability were evaluated as well as 
      the inter-observer agreement (k). RESULTS: EDI-OCT demonstrated a sensitivity of 
      92% (95% CI: 83%-96%), a specificity of 96% (95% CI: 87%-99%), with a positive 
      predictive value of 97% and a negative predictive value of 89%. The 
      inter-observer agreement was as remarkable as k = 0.8985 (95% CI 0.8252-0.9718). 
      A positive EDI OCT increases the posttest probability to 97% (95% CI: 91%-99%); 
      when negative, the posttest probability is reduced to 12% (95% CI: 6%-21%). 
      CONCLUSION: EDI-OCT allowed for differentiation between ONHD and ODE with high 
      sensitivity and specificity.
FAU - Gili, Pablo
AU  - Gili P
AUID- ORCID: 0000-0002-5013-4459
AD  - Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Kim-Yeon, Naon
AU  - Kim-Yeon N
AD  - Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
AD  - Hospital Universitario de Torrejon, Torrejon de Ardoz, Madrid, Spain.
FAU - de Manuel-Triantafilo, Sofia
AU  - de Manuel-Triantafilo S
AD  - Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
AD  - Hospital Universitario la Paz, Madrid, Spain.
FAU - Modamio-Gardeta, Laura
AU  - Modamio-Gardeta L
AD  - Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
AD  - Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.
FAU - Leal-Gonzalez, Mercedes
AU  - Leal-Gonzalez M
AD  - Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Yanguela, Julio
AU  - Yanguela J
AD  - Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210112
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Optic Disk
MH  - *Optic Disk Drusen/diagnostic imaging
MH  - *Papilledema/diagnosis
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Optical coherence tomography
OT  - enhanced depth imaging
OT  - optic disc drusen
OT  - optic disc oedema
OT  - sensitivity
OT  - specificity
EDAT- 2021/01/14 06:00
MHDA- 2021/11/24 06:00
CRDT- 2021/01/13 05:41
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2021/01/13 05:41 [entrez]
AID - 10.1177/1120672120986374 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2021 Nov;31(6):3476-3482. doi: 10.1177/1120672120986374. Epub 
      2021 Jan 12.