PMID- 33435778
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 49
IP  - 1
DP  - 2021 Jan
TI  - Multiple endocrine neoplasia type 1 with refractory hypoglycemia and lung and 
      liver metastases: a case report.
PG  - 300060520961682
LID - 10.1177/0300060520961682 [doi]
LID - 0300060520961682
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal 
      dominant genetic disease. MEN1 with multiple endocrine adenomatosis complicated 
      by multiple endocrine tumors is often misdiagnosed or missed. Herein, we describe 
      the first reported case of refractory hypoglycemia and liver and lung metastases 
      in a patient with MEN1.Case presentation: A 40-year-old man presented with a 
      3-month history of intermittent palpitations, fatigue, and sweating. The patient 
      had a history of prolactinoma resection and refractory hypoglycemia 2 years 
      earlier. Analyses of blood samples showed a decrease in random and fasting blood 
      glucose and an increase in prolactin (PRL). Computed tomography (CT) and magnetic 
      resonance imaging scans revealed two substantial masses in the pancreas and large 
      masses in the liver and lung. Positron emission tomography-CT images showed 
      hypermetabolic masses in the pancreatic body and tail. The liver and lung lesions 
      were also hypermetabolic. The pancreatic lesion was surgically removed, and 
      pathology confirmed that the mass was MEN1. The liver and lung masses were 
      confirmed as metastatic tumors. CONCLUSION: If clinicians better understand MEN1, 
      they can obtain a detailed patient and family history during the initial visit, 
      allowing earlier diagnosis and intervention and improved prognosis.
FAU - Wang, Yong
AU  - Wang Y
AUID- ORCID: 0000-0001-5869-2044
AD  - Department of Radiology, the First Hospital of Hebei Medical University, 
      Shijiazhuang 050000, China.
FAU - Zhang, Hui
AU  - Zhang H
AD  - Department of Radiology, Hebei General Hospital, Shijiazhuang 050000, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Hypoglycemia
MH  - *Liver Neoplasms/diagnostic imaging
MH  - Lung
MH  - Male
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnostic imaging
MH  - *Pancreatic Neoplasms/complications/diagnostic imaging
MH  - *Pituitary Neoplasms
PMC - PMC7809309
OTO - NOTNLM
OT  - Multiple endocrine neoplasia
OT  - computed tomography
OT  - magnetic resonance imaging
OT  - positron emission tomography-computed tomography
OT  - prolactin
OT  - refractory hypoglycemia
COIS- Declaration of conflicting interest: The authors declare that there is no 
      conflict of interest.
EDAT- 2021/01/14 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/01/12
CRDT- 2021/01/13 05:41
PHST- 2021/01/13 05:41 [entrez]
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/01/12 00:00 [pmc-release]
AID - 10.1177_0300060520961682 [pii]
AID - 10.1177/0300060520961682 [doi]
PST - ppublish
SO  - J Int Med Res. 2021 Jan;49(1):300060520961682. doi: 10.1177/0300060520961682.