PMID- 33438366
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20210701
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 8
IP  - 2
DP  - 2021 Apr
TI  - Incremental prognostic value of cardiac metaiodobenzylguanidine imaging over the 
      co-morbid burden in acute decompensated heart failure.
PG  - 1167-1177
LID - 10.1002/ehf2.13173 [doi]
AB  - AIMS: Co-morbidities are associated with poor clinical outcomes in patients with 
      chronic heart failure, while cardiac iodine-123 (I-123) metaiodobenzylguanidine 
      (MIBG) imaging provides prognostic information in such patients. We sought to 
      prospectively investigate the incremental prognostic value of cardiac MIBG 
      imaging over the co-morbid burden, in patients admitted for acute decompensated 
      heart failure (ADHF). METHODS AND RESULTS: In 433 consecutive ADHF patients with 
      survival to discharge, we measured the co-morbidity using age-adjusted Charlson 
      co-morbidity index (ACCI), commonly employed to evaluate a weighted and scored 
      co-morbid condition, adding additional points for age. In cardiac MIBG imaging, 
      the cardiac MIBG heart-to-mediastinum ratio (late HMR) was measured on the 
      delayed image. Over a follow-up period of 2.9 +/- 1.5 years, 160 patients had a 
      cardiac event (a composite of cardiac death and unplanned hospitalization for 
      worsening heart failure). Patients with high ACCI (>/=6: median value) had a 
      significantly greater risk of a cardiac event. In multivariate Cox analysis, the 
      ACCI and late HMR were significantly and independently associated with a cardiac 
      event. In both high and low ACCI subgroups (ACCI >/= 6 and <6, respectively), 
      patients with low late HMR had a significantly greater risk of a cardiac event 
      (high ACCI: 51% vs. 34% P = 0.0026, adjusted HR 1.74 [1.21-2.51]; low ACCI: 34% 
      vs. 17%, P = 0.0228, adjusted HR 2.19 [1.10-4.37]). CONCLUSIONS: Cardiac MIBG 
      imaging could provide additional prognostic information over ACCI, which was also 
      promoted to be a useful risk model, in patients admitted for ADHF.
CI  - (c) 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on 
      behalf of European Society of Cardiology.
FAU - Kayama, Kiyomi
AU  - Kayama K
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Yamada, Takahisa
AU  - Yamada T
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Tamaki, Shunsuke
AU  - Tamaki S
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Watanabe, Tetsuya
AU  - Watanabe T
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Morita, Takashi
AU  - Morita T
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Furukawa, Yoshio
AU  - Furukawa Y
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Kawasaki, Masato
AU  - Kawasaki M
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Kikuchi, Atsushi
AU  - Kikuchi A
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Kawai, Tsutomu
AU  - Kawai T
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Seo, Masahiro
AU  - Seo M
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Nakamura, Jun
AU  - Nakamura J
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Kawahira, Masatsugu
AU  - Kawahira M
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
FAU - Fukunami, Masatake
AU  - Fukunami M
AD  - Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210112
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - *3-Iodobenzylguanidine
MH  - Heart
MH  - *Heart Failure/diagnosis/epidemiology
MH  - Humans
MH  - Prognosis
MH  - Radiopharmaceuticals
PMC - PMC8006734
OTO - NOTNLM
OT  - Acute decompensated heart failure
OT  - Age-adjusted co-morbidity index
OT  - Cardiac MIBG imaging
OT  - Co-morbidity
OT  - Prognosis
COIS- None declared.
EDAT- 2021/01/14 06:00
MHDA- 2021/07/02 06:00
PMCR- 2021/01/12
CRDT- 2021/01/13 06:19
PHST- 2020/11/03 00:00 [revised]
PHST- 2020/07/24 00:00 [received]
PHST- 2020/11/27 00:00 [accepted]
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2021/01/13 06:19 [entrez]
PHST- 2021/01/12 00:00 [pmc-release]
AID - EHF213173 [pii]
AID - 10.1002/ehf2.13173 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2021 Apr;8(2):1167-1177. doi: 10.1002/ehf2.13173. Epub 2021 Jan 
      12.