PMID- 33438411
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210114
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 5
IP  - 9
DP  - 2019 Sep 9
TI  - Polymeric Vector-Mediated Targeted Delivery of Anti-PAK1 siRNA to Macrophages for 
      Efficient Atherosclerosis Treatment.
PG  - 4455-4462
LID - 10.1021/acsbiomaterials.9b01076 [doi]
AB  - Atherogenesis, initially induced by endothelial structure alteration and 
      dysfunction, is the main cause of cardiovascular diseases that jeopardize public 
      health. Unfortunately, an efficient strategy for atherosclerosis treatment is 
      still far from satisfying the clinical requirements. Dyslipidemia and chronic 
      inflammatory responses, especially the overexpression of the pro-atherosclerotic 
      factors monocyte chemotactic protein 1 (MCP-1) and interleukin-6 (IL-6) in 
      plaques, represent the key features that promote the development of 
      atherosclerosis. Here, a CD36 antibody-modified small-interfering RNA (siRNA) 
      nanomedicine based on the mPEG-PAsp-(g-PEI) vector was developed for 
      atherosclerosis therapy. In vitro and in vivo studies demonstrated that the 
      synthesized siRNA nanomedicine targeted macrophages, reduced CD36 expression, and 
      inhibited IL-6 and MCP-1 upregulation, and eventually reduced the formation of 
      foam cells and alleviated the pathological process of atherosclerosis. These 
      results indicate that the targeted delivery of anti-PAK1 siRNA using a CD36 
      antibody-modified polymeric vector represents a novel and efficient strategy for 
      atherosclerosis treatment.
FAU - Wu, Teng
AU  - Wu T
AD  - Department of Hypertension and Vascular Disease, the First Affiliated Hospital, 
      Sun Yat-Sen University, Guangzhou 510080, China.
AD  - PCFM Lab of Ministry of Education, School of Materials Science and Engineering, 
      Sun Yat-sen University, Guangzhou 510275, China.
FAU - Xiao, Hong
AU  - Xiao H
AD  - PCFM Lab of Ministry of Education, School of Materials Science and Engineering, 
      Sun Yat-sen University, Guangzhou 510275, China.
AD  - College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, 
      China.
FAU - Lu, Liejing
AU  - Lu L
AD  - Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou 510120, Guangdong, China.
FAU - Chen, Yali
AU  - Chen Y
AD  - Department of Hypertension and Vascular Disease, the First Affiliated Hospital, 
      Sun Yat-Sen University, Guangzhou 510080, China.
FAU - Wang, Yong
AU  - Wang Y
AUID- ORCID: 0000-0002-8349-7555
AD  - PCFM Lab of Ministry of Education, School of Materials Science and Engineering, 
      Sun Yat-sen University, Guangzhou 510275, China.
AD  - College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, 
      China.
FAU - Xia, Wenhao
AU  - Xia W
AD  - Department of Hypertension and Vascular Disease, the First Affiliated Hospital, 
      Sun Yat-Sen University, Guangzhou 510080, China.
FAU - Long, Ming
AU  - Long M
AD  - Department of Hypertension and Vascular Disease, the First Affiliated Hospital, 
      Sun Yat-Sen University, Guangzhou 510080, China.
FAU - Tao, Jun
AU  - Tao J
AD  - Department of Hypertension and Vascular Disease, the First Affiliated Hospital, 
      Sun Yat-Sen University, Guangzhou 510080, China.
FAU - Shen, Jun
AU  - Shen J
AUID- ORCID: 0000-0001-7746-5285
AD  - Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou 510120, Guangdong, China.
FAU - Shuai, Xintao
AU  - Shuai X
AUID- ORCID: 0000-0003-4271-0310
AD  - Department of Hypertension and Vascular Disease, the First Affiliated Hospital, 
      Sun Yat-Sen University, Guangzhou 510080, China.
AD  - PCFM Lab of Ministry of Education, School of Materials Science and Engineering, 
      Sun Yat-sen University, Guangzhou 510275, China.
LA  - eng
PT  - Journal Article
DEP - 20190823
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - CD36 targeting
OT  - anti-inflammatory
OT  - atherosclerosis
OT  - macrophages
OT  - siRNA delivery
EDAT- 2019/09/09 00:00
MHDA- 2019/09/09 00:01
CRDT- 2021/01/13 08:37
PHST- 2021/01/13 08:37 [entrez]
PHST- 2019/09/09 00:00 [pubmed]
PHST- 2019/09/09 00:01 [medline]
AID - 10.1021/acsbiomaterials.9b01076 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2019 Sep 9;5(9):4455-4462. doi: 
      10.1021/acsbiomaterials.9b01076. Epub 2019 Aug 23.