PMID- 33438572
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 2212-3873 (Electronic)
IS  - 1871-5303 (Linking)
VI  - 21
IP  - 11
DP  - 2021
TI  - Association between Proliferative Diabetic Retinopathy and Serum Bile Acid Level 
      in Patients with Type 2 Diabetes Mellitus.
PG  - 2063-2067
LID - 10.2174/1871530321666210112160724 [doi]
AB  - BACKGROUND: Diabetic retinopathy (DR) is one of the diabetic microvascular 
      complications, which is also one of the important causes of blindness in adults. 
      OBJECTIVE: To investigate the association between proliferative retinopathy and 
      serum bile acid level in patients with type 2 diabetes mellitus (T2DM). METHODS: 
      Three hundred and thirty-six patients with T2DM were included, of which, 229 had 
      a history of more than 10 years without diabetic retinopathy (no diabetic 
      retinopathy, NDR) and 107 had proliferative diabetic retinopathy (PDR). The 
      baseline characteristics of the two groups were compared. According to the level 
      of bile acid, the patients were divided into low, medium and high bile acid 
      groups. The ratio of proliferative retinopathy in each group was compared. The 
      presence of retinopathy was taken as the dependent variable, and the significant 
      variables were analyzed by logistic regression. RESULTS: The level of total 
      bilirubin and bile acid in the NDR group was significantly higher than that in 
      the PDR group, while the levels of triglyceride, cholesterol and LDL-C were 
      significantly lower than that in the PDR group (P<0.05). With the increase of 
      bile acid level, the proportion of proliferative retinopathy decreased. Logistic 
      regression analysis showed that bilirubin and bile acid were protective factors 
      of diabetic retinopathy, while SBP, LDL-C and UAER were risk factors of diabetic 
      retinopathy. CONCLUSION: Bile acid might be a protective factor for diabetic 
      retinopathy in T2DM, which might be a potential therapeutic role in retinal 
      disorders.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Su, Zhiyan
AU  - Su Z
AD  - Department of Endocrinology, Tongren Hospital, Capital Medical University, 
      Dongcheng District, Beijing, 100730,China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Endocrinology, Tongren Hospital, Capital Medical University, 
      Dongcheng District, Beijing, 100730,China.
FAU - Yang, Jinkui
AU  - Yang J
AD  - Department of Endocrinology, Tongren Hospital, Capital Medical University, 
      Dongcheng District, Beijing, 100730,China.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Endocr Metab Immune Disord Drug Targets
JT  - Endocrine, metabolic & immune disorders drug targets
JID - 101269157
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Bile Acids and Salts
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology
MH  - *Diabetic Retinopathy/diagnosis/epidemiology/etiology
MH  - Humans
MH  - Risk Factors
MH  - Triglycerides
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - diabetic retinopathy
OT  - oxidative stress
OT  - serum bile acid
OT  - tauroursodeoxycholic acid
OT  - ursodeoxycholic acid.
EDAT- 2021/01/14 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/01/13 08:37
PHST- 2020/06/29 00:00 [received]
PHST- 2020/09/09 00:00 [revised]
PHST- 2020/10/17 00:00 [accepted]
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/01/13 08:37 [entrez]
AID - EMIDDT-EPUB-113243 [pii]
AID - 10.2174/1871530321666210112160724 [doi]
PST - ppublish
SO  - Endocr Metab Immune Disord Drug Targets. 2021;21(11):2063-2067. doi: 
      10.2174/1871530321666210112160724.