PMID- 33439570 OWN - NLM STAT- MEDLINE DCOM- 20220314 LR - 20220314 IS - 2724-6442 (Electronic) IS - 2724-6051 (Linking) VI - 74 IP - 1 DP - 2022 Feb TI - Health-related quality of life 24 months after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study. PG - 11-20 LID - 10.23736/S2724-6051.20.04032-1 [doi] AB - BACKGROUND: This study analyzes patient health-related quality of life (QoL) 24-month after prostate cancer (PCa) diagnosis within the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study. METHODS: Pros-IT CNR is an ongoing, longitudinal and observational study, considering a convenience sample of patients enrolled at PCa diagnosis and followed at 6, 12, 24, 36, 48 and 60 months from the diagnosis. Patients were grouped according to the treatment received: nerve sparing radical prostatectomy (NSRP), non-nerve sparing radical prostatectomy (NNSRP), radiotherapy (RT), RT plus androgen deprivation (RT plus ADT) and active surveillance (AS). QoL was measured through the Italian versions of SF-12 and UCLA-PCI questionnaires at diagnosis and at 6-12 and 24-month. The minimal clinically important difference (MCID) was defined as half a standard deviation of the baseline domain. RESULTS: Overall, 1537 patients were included in the study. The decline in urinary function exceeded the MCID at each timepoint only in the NSRP and NNSRP groups (at 24 months -14.7, P<0.001 and -19.7, P<0.001, respectively). The decline in bowel function exceeded the MCID only in the RT (-9.1, P=0.02) and RT plus ADT groups at 12 months (-10.3, P=0.001); after 24 months, most patients seem to recover their bowel complaints. The decline in sexual function exceeded the MCID at each timepoint in the NNSRP, NSRP and RT plus ADT groups (at 6 months -28.7, P<0.001, -37.8, P<0.001, -20.4, P<0.001, respectively). CONCLUSIONS: Although all the treatments were relatively well-tolerated over the 24 month period following PCa diagnosis, each had a different impact on QoL. FAU - Palumbo, Carlotta AU - Palumbo C AD - Department of Urology, Maggiore della Carita Hospital, Novara, Italy. FAU - Bruni, Alessio AU - Bruni A AD - Unit of Radiotherapy, University Hospital of Modena, Modena, Italy. FAU - Antonelli, Alessandro AU - Antonelli A AD - Department of Urology, University of Verona, Verona, Italy. FAU - Artibani, Walter AU - Artibani W AD - Italian Society of Urology, Rome, Italy. FAU - Bassi, Pierfrancesco AU - Bassi P AD - Department of Urology, IRCCS A. Gemelli University Polyclinic Foundation, Sacred Heart Catholic University, Rome, Italy. FAU - Bertoni, Filippo AU - Bertoni F AD - Prostate Group of the Italian Association for Radiation Oncology (AIRO), Milan, Italy. FAU - Borghetti, Paolo AU - Borghetti P AD - Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy. FAU - Bracarda, Sergio AU - Bracarda S AD - Azienda Ospedaliera S. Maria, Terni, Italy. FAU - Cicchetti, Alessandro AU - Cicchetti A AD - Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. FAU - Corvo, Renzo AU - Corvo R AD - Department of Radiation Oncology, IRCCS San Martino University Hospital, University of Genoa, Genoa, Italy. FAU - Gacci, Mauro AU - Gacci M AD - Department of Urologic Robotic Surgery and Renal Transplantation, Careggi Hospital, University of Florence, Florence, Italy. FAU - Ingrosso, Gianluca AU - Ingrosso G AD - Section of Radiation Oncology, Department of Surgical and Biomedical Science, University of Perugia, Perugia, Italy. FAU - Magrini, Stefano M AU - Magrini SM AD - Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy. FAU - Maruzzo, Marco AU - Maruzzo M AD - Medical Oncology Unit 1, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy. FAU - Mirone, Vincenzo AU - Mirone V AD - Department of Urology, University of Naples Federico II, Naples, Italy. FAU - Montironi, Rodolfo AU - Montironi R AD - Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, Italy. FAU - Muto, Giovanni AU - Muto G AD - Department of Urology, Humanitas Gradenigo University Hospital, Turin, Italy. FAU - Noale, Marianna AU - Noale M AD - National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy - marianna.noale@in.cnr.it. FAU - Porreca, Angelo AU - Porreca A AD - Department of Robotic Urological Surgery, Abano Terme Hospital, Abano Terme, Italy. FAU - Russi, Elvio AU - Russi E AD - Department of Radiotherapy, S. Croce e Carle Teaching Hospital, Cuneo, Italy. FAU - Triggiani, Luca AU - Triggiani L AD - Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy. FAU - Tubaro, Andrea AU - Tubaro A AD - Unit of Urology, Sant'Andrea Hospital, La Sapienza University of Rome, Rome, Italy. FAU - Valdagni, Riccardo AU - Valdagni R AD - Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. FAU - Maggi, Stefania AU - Maggi S AD - National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy. FAU - Conti, Giario N AU - Conti GN AD - Department of Urology, Sant'Anna Hospital, Como, Italy. CN - Pros-IT CNR Study Group LA - eng PT - Journal Article PT - Observational Study DEP - 20210113 PL - Italy TA - Minerva Urol Nephrol JT - Minerva urology and nephrology JID - 101777299 RN - 0 (Androgen Antagonists) SB - IM MH - Androgen Antagonists/therapeutic use MH - Humans MH - Male MH - *Percutaneous Coronary Intervention MH - Prostatectomy MH - *Prostatic Neoplasms/diagnosis/therapy MH - Quality of Life FIR - Alitto, Anna R IR - Alitto AR FIR - Ambrosi, Enrica IR - Ambrosi E FIR - Antonelli, Alessandro IR - Antonelli A FIR - Aristei, Cynthia IR - Aristei C FIR - Barbieri, Michele IR - Barbieri M FIR - Bardari, Franco IR - Bardari F FIR - Bardoscia, Lilia IR - Bardoscia L FIR - Barra, Salvina IR - Barra S FIR - Bartoncini, Sara IR - Bartoncini S FIR - Basso, Umberto IR - Basso U FIR - Becherini, Carlotta IR - Becherini C FIR - Bellavita, Rita IR - Bellavita R FIR - Bergamaschi, Franco IR - Bergamaschi F FIR - Berlingheri, Stefania IR - Berlingheri S FIR - Berruti, Alfredo IR - Berruti A FIR - 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Graziotti P FIR - Maurizi Enrici, Riccardo IR - Maurizi Enrici R FIR - Mirone, Vincenzo IR - Mirone V FIR - Montironi, Rodolfo IR - Montironi R FIR - Bertoni, Filippo IR - Bertoni F FIR - Gacci, Mauro IR - Gacci M FIR - Magrini, Stefano M IR - Magrini SM FIR - Muto, Giovanni IR - Muto G FIR - Pecoraro, Stefano IR - Pecoraro S FIR - Ricardi, Umberto IR - Ricardi U FIR - Tubaro, Andrea IR - Tubaro A FIR - Zagonel, Vittorina IR - Zagonel V EDAT- 2021/01/14 06:00 MHDA- 2022/03/15 06:00 CRDT- 2021/01/13 12:41 PHST- 2021/01/14 06:00 [pubmed] PHST- 2022/03/15 06:00 [medline] PHST- 2021/01/13 12:41 [entrez] AID - S0393-2249.20.04032-1 [pii] AID - 10.23736/S2724-6051.20.04032-1 [doi] PST - ppublish SO - Minerva Urol Nephrol. 2022 Feb;74(1):11-20. doi: 10.23736/S2724-6051.20.04032-1. Epub 2021 Jan 13.