PMID- 33439762
OWN - NLM
STAT- MEDLINE
DCOM- 20211216
LR  - 20220402
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Print)
IS  - 1540-4196 (Linking)
VI  - 19
IP  - 3
DP  - 2021 Apr
TI  - Risk Factors and Wellness Measures Associated with Prediabetes and Newly 
      Diagnosed Type 2 Diabetes Mellitus in Hispanic Adults.
PG  - 180-189
LID - 10.1089/met.2020.0102 [doi]
AB  - Background: To characterize the associations of clinical risk factors, lifestyle 
      factors, and wellness measures with prediabetes and new type 2 diabetes mellitus 
      (T2DM) diagnosis in Hispanic adults and guide primary prevention. Methods:Sangre 
      Por Salud Biobank enrolled 3733 Hispanic adults from Phoenix, AZ, United States, 
      from 2013 to 2018. This analysis included participants with euglycemia, 
      prediabetes, or new T2DM diagnosis (i.e., no prior T2DM diagnosis) at enrollment. 
      Participants completed a baseline questionnaire on cardiometabolic risk factors 
      and wellness measures and provided biometric measurements. The associations of 
      factors and measures with odds (95% confidence interval) of prediabetes and new 
      T2DM diagnosis were analyzed in logistic regression models. Results: Among 3299 
      participants with euglycemia (n = 1301), prediabetes (n = 1718), and new T2DM 
      diagnosis (n = 280) at enrollment, 72% were women (n = 2376/3299). In adjusted 
      models, most cardiometabolic risk factors were positively associated with 
      prediabetes and new T2DM diagnosis, with stronger associations for new T2DM 
      diagnosis. Obesity (body mass index >/=30 kg/m(2) vs. lower) was associated with 
      higher odds of new T2DM diagnosis (3.14 [2.30-4.28]; P < 0.01) than prediabetes 
      versus euglycemia (1.96 [1.66-2.32]; P < 0.01) and Interaction (P = 0.01). 
      Similarly, waist circumference, family history of diabetes, and average systolic 
      and diastolic blood pressure were associated with higher odds of new T2DM 
      diagnosis versus euglycemia than prediabetes versus euglycemia. Using stepwise 
      logistic regression modeling, a parsimonious model of age, family history of 
      diabetes, waist circumference, diastolic blood pressure, passive tobacco 
      exposure, and self-rated general health were associated with new T2DM diagnosis 
      versus euglycemia. Conclusions: In Hispanic adults, modifiable cardiometabolic 
      and lifestyle factors were associated with prediabetes and new T2DM diagnosis. 
      Personalized interventions targeting these factors and measures could guide T2DM 
      primary prevention efforts among Hispanic adults.
FAU - Dugani, Sagar B
AU  - Dugani SB
AD  - Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Girardo, Marlene E
AU  - Girardo ME
AD  - Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona, USA.
FAU - De Filippis, Eleanna
AU  - De Filippis E
AD  - Department of Endocrinology, Mayo Clinic, Scottsdale, Arizona, USA.
FAU - Mielke, Michelle M
AU  - Mielke MM
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
AD  - Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Vella, Adrian
AU  - Vella A
AD  - Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
LA  - eng
GR  - KL2 TR002379/TR/NCATS NIH HHS/United States
GR  - R01 AG049704/AG/NIA NIH HHS/United States
GR  - UL1 TR002377/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210115
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
SB  - IM
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Female
MH  - Hispanic or Latino
MH  - Humans
MH  - *Prediabetic State/diagnosis/epidemiology
MH  - Risk Factors
MH  - Waist Circumference
PMC - PMC7997711
OTO - NOTNLM
OT  - Hispanic health
OT  - prediabetes
OT  - primary prevention
OT  - risk factors
OT  - type 2 diabetes
COIS- No conflicting financial interests exist.
EDAT- 2021/01/14 06:00
MHDA- 2021/12/17 06:00
PMCR- 2022/04/01
CRDT- 2021/01/13 17:09
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2021/12/17 06:00 [medline]
PHST- 2021/01/13 17:09 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.1089/met.2020.0102 [pii]
AID - 10.1089/met.2020.0102 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2021 Apr;19(3):180-189. doi: 10.1089/met.2020.0102. 
      Epub 2021 Jan 15.