PMID- 33440030
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20210428
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 63
IP  - 4
DP  - 2021 Apr
TI  - Chronic idiopathic axonal polyneuropathy: Electrophysiological progression and 
      human leukocyte antigen associations.
PG  - 567-571
LID - 10.1002/mus.27164 [doi]
AB  - BACKGROUND: We aimed to describe the electrophysiological progression rate of 
      chronic idiopathic axonal polyneuropathy (CIAP) and look into the potential role 
      of human leukocyte antigen (HLA) genetic susceptibility in its development. 
      METHODS: We recruited 57 patients with CIAP (mean age at diagnosis 67, mean 
      follow-up 7 years). The assessments included clinical and electrophysiological 
      data and HLA-DQ genotyping. RESULTS: The DQA1*05 allele was found more frequently 
      in patients than in healthy controls (odds ratio, 1.96, P = .011). In patients 
      with length-dependent CIAP, a linear effect of time on the electrophysiological 
      findings was found in the superficial radial (3.2% mean annual decrement, P 
      < .001), sural (4.7% mean annual decrement, P = .002) and tibial nerve (6.1% mean 
      annual decrement, P = .007) amplitudes, independently from age or gender. 
      CONCLUSIONS: Patients with length-dependent CIAP, show a linear progression over 
      time. Interesting associations of HLA-DQA1*05 allele with length-dependent CIAP 
      and non-DQ2/DQ8 with idiopathic sensory ganglionopathy were found. These merit 
      further investigation in larger cohorts and may suggest a role of the immune 
      system in the pathogenesis of CIAP.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Zis, Panagiotis
AU  - Zis P
AUID- ORCID: 0000-0001-8567-3092
AD  - Academic Directorate of Neurosciences, Sheffield Teaching Hospitals NHS 
      Foundation Trust, Sheffield, UK.
AD  - Medical School, University of Cyprus, Nicosia, Cyprus.
FAU - Sarrigiannis, Ptolemaios G
AU  - Sarrigiannis PG
AD  - Academic Directorate of Neurosciences, Sheffield Teaching Hospitals NHS 
      Foundation Trust, Sheffield, UK.
FAU - Artemiadis, Artemios
AU  - Artemiadis A
AD  - Medical School, University of Cyprus, Nicosia, Cyprus.
FAU - Skarlatou, Vasiliki
AU  - Skarlatou V
AD  - Academic Directorate of Neurosciences, Sheffield Teaching Hospitals NHS 
      Foundation Trust, Sheffield, UK.
AD  - Department of Neurology, Evangelismos General Hospital, Athens, Greece.
FAU - Hadjivassiliou, Marios
AU  - Hadjivassiliou M
AD  - Academic Directorate of Neurosciences, Sheffield Teaching Hospitals NHS 
      Foundation Trust, Sheffield, UK.
LA  - eng
PT  - Journal Article
DEP - 20210116
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Axons/*pathology
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polyneuropathies/diagnosis/*pathology
MH  - Sex Factors
MH  - Tibial Nerve/*pathology
OTO - NOTNLM
OT  - CIAP
OT  - HLA genotyping
OT  - idiopathic
OT  - natural history
OT  - peripheral neuropathy
EDAT- 2021/01/14 06:00
MHDA- 2021/04/29 06:00
CRDT- 2021/01/13 17:11
PHST- 2020/12/29 00:00 [revised]
PHST- 2020/05/28 00:00 [received]
PHST- 2020/12/31 00:00 [accepted]
PHST- 2021/01/14 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2021/01/13 17:11 [entrez]
AID - 10.1002/mus.27164 [doi]
PST - ppublish
SO  - Muscle Nerve. 2021 Apr;63(4):567-571. doi: 10.1002/mus.27164. Epub 2021 Jan 16.