PMID- 33441966
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20230127
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 18
IP  - 2
DP  - 2021 Feb
TI  - Early-life EV-A71 infection augments allergen-induced airway inflammation in 
      asthma through trained macrophage immunity.
PG  - 472-483
LID - 10.1038/s41423-020-00621-4 [doi]
AB  - Virus-induced asthma is prevalent among children, but its underlying mechanisms 
      are unclear. Accumulated evidence indicates that early-life respiratory virus 
      infection increases susceptibility to allergic asthma. Nonetheless, the 
      relationship between systemic virus infections, such as enterovirus infection, 
      and the ensuing effects on allergic asthma development is unknown. Early-life 
      enterovirus infection was correlated with higher risks of allergic diseases in 
      children. Adult mice exhibited exacerbated mite allergen-induced airway 
      inflammation following recovery from EV-A71 infection in the neonatal period. 
      Bone marrow-derived macrophages (BMDMs) from recovered EV-A71-infected mice 
      showed sustained innate immune memory (trained immunity) that could drive naive T 
      helper cells toward Th2 and Th17 cell differentiation when in contact with mites. 
      Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation 
      in naive recipient mice, which was inhibited by 2-deoxy-D-glucose (2-DG) 
      pretreatment, suggesting that trained macrophages following enterovirus infection 
      are crucial in the progression of allergic asthma later in life.
FAU - Chen, Pei-Chi
AU  - Chen PC
AD  - Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan, China.
FAU - Shao, Yu-Ting
AU  - Shao YT
AD  - Department of Microbiology and Immunology, College of Medicine, National Cheng 
      Kung University, Tainan, Taiwan, China.
FAU - Hsieh, Miao-Hsi
AU  - Hsieh MH
AD  - Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan, China.
FAU - Kao, Hui-Fang
AU  - Kao HF
AD  - Center for Allergy and Clinical Immunology Research, College of Medicine, 
      National Cheng Kung University, Tainan, Taiwan, China.
AD  - Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan, 
      China.
FAU - Kuo, Wen-Shuo
AU  - Kuo WS
AD  - Center for Allergy and Clinical Immunology Research, College of Medicine, 
      National Cheng Kung University, Tainan, Taiwan, China.
AD  - School of Chemistry and Materials Science, Nanjing University of Information 
      Science and Technology, Nanjing, China.
FAU - Wang, Shih-Min
AU  - Wang SM
AD  - Department of Pediatrics, National Cheng Kung University Hospital, Tainan, 
      Taiwan, China.
FAU - Chen, Shun-Hua
AU  - Chen SH
AD  - Department of Microbiology and Immunology, College of Medicine, National Cheng 
      Kung University, Tainan, Taiwan, China.
FAU - Wu, Lawrence Shih Hsin
AU  - Wu LSH
AD  - Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 
      Taiwan, China.
FAU - Tsai, Hui-Ju
AU  - Tsai HJ
AD  - Division of Biostatistics and Bioinformatics, Institute of Population Health 
      Sciences, National Health Research Institutes, Zhunan, Taiwan, China.
FAU - Wang, Jiu-Yao
AU  - Wang JY
AUID- ORCID: 0000-0003-4540-9822
AD  - Center for Allergy and Clinical Immunology Research, College of Medicine, 
      National Cheng Kung University, Tainan, Taiwan, China. a122@mail.ncku.edu.tw.
AD  - Department of Pediatrics, National Cheng Kung University Hospital, Tainan, 
      Taiwan, China. a122@mail.ncku.edu.tw.
AD  - Department of Pediatrics, National Cheng Kung University Hospital, No, 139, 
      Sheng-Li Road, Tainan, 70428, Taiwan, China. a122@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210113
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*adverse effects
MH  - Animals
MH  - Animals, Newborn
MH  - Asthma/epidemiology/immunology/*pathology/virology
MH  - Cell Differentiation
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Enterovirus A, Human/*isolation & purification
MH  - Enterovirus Infections/*complications/virology
MH  - Humans
MH  - *Immunity, Innate
MH  - Immunologic Memory
MH  - Inflammation/epidemiology/immunology/*pathology/virology
MH  - Macrophages/*immunology/virology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pyroglyphidae
MH  - Th17 Cells/immunology/virology
MH  - Th2 Cells/immunology/virology
PMC - PMC8027667
OTO - NOTNLM
OT  - allergy
OT  - asthma
OT  - trained immunity
COIS- The authors declare no competing interests.
EDAT- 2021/01/15 06:00
MHDA- 2021/12/28 06:00
PMCR- 2022/02/01
CRDT- 2021/01/14 05:42
PHST- 2020/09/19 00:00 [received]
PHST- 2020/12/07 00:00 [accepted]
PHST- 2021/01/15 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2021/01/14 05:42 [entrez]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 10.1038/s41423-020-00621-4 [pii]
AID - 621 [pii]
AID - 10.1038/s41423-020-00621-4 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2021 Feb;18(2):472-483. doi: 10.1038/s41423-020-00621-4. Epub 
      2021 Jan 13.