PMID- 33442152
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 0857-1074 (Print)
IS  - 2308-118X (Electronic)
IS  - 0857-1074 (Linking)
VI  - 34
IP  - 2
DP  - 2019
TI  - Insulin Resistance and beta-Cell Function of Lean versus Overweight or Obese 
      Filipino Patients with Newly Diagnosed Type 2 Diabetes Mellitus.
PG  - 164-170
LID - 10.15605/jafes.034.02.07 [doi]
AB  - OBJECTIVES: To compare the level of insulin resistance and beta-cell function 
      between lean and overweight/obese Filipino patients with newly diagnosed type 2 
      diabetes mellitus (T2DM). METHODOLOGY: This was a cross-sectional analytical 
      study including newly diagnosed T2DM Filipino patients from St. Luke's Medical 
      Center - Quezon City. The patients were classified as either lean or 
      overweight/obese. Age, sex, smoking history, anthropometric measures and blood 
      pressure were obtained. Insulin resistance and beta-cell function were determined 
      using the homeostasis model assessment (HOMA). The original model (HOMA1) and the 
      updated model (HOMA2) were used. RESULTS: A total of 80 subjects were included. 
      There were 40 subjects in each group. The overweight/obese subjects had 
      significantly higher mean insulin resistance (HOMA1-IR 9.8+/-11.7, HOMA2-IR 
      3.0+/-2.0) compared to the lean group (HOMA1-IR 2.9+/-1.5, HOMA2-IR 1.3+/-0.5). This 
      was consistent in both HOMA1 and HOMA2 (p-values=0.001 and <0.001, respectively). 
      The mean beta-cell function of the overweight/obese patients was significantly 
      higher than the lean subjects when using HOMA1 (lean=57.8+/-35.5, 
      overweight/obese=93.6+/-66.4, p-value=0.003), but not in HOMA2 (lean=57.6+/-30.5, 
      overweight/obese=74.8+/-45.7, p-value=0.051). Overweight/obesity increased HOMA1-IR 
      by 4.0 and HOMA1-B by 46.1 (p-values= 0.002 and <0.001, respectively). Through 
      the use of HOMA2, overweight/obesity increased HOMA2-IR by 1.4 and HOMA2-B by 
      29.1 (p-values<0.001). Being overweight/obese was also associated with 
      significantly higher odds for developing greater insulin resistance (HOMA1-IR 
      adjOR = 5.6, 95%CI= 1.7-19.2, p-value=0.005; HOMA2-IR adjOR=10.9, 95%CI=3.4-34.9, 
      p-value<0.001) and lower odds for a decreased beta-cell function (HOMA1-B adjOR = 
      0.2, 95%CI = 0.05-0.9, p-value=0.033; HOMA2-B adjOR=0.2, 95%CI=0.04-0.9, 
      p-value=0.043) compared to being lean. CONCLUSION: Newly diagnosed 
      overweight/obese T2DM had higher mean insulin resistance and beta-cell function 
      compared to lean T2DM. Overweight/obesity was also associated with higher odds of 
      developing insulin resistance and lower odds for a decreased beta-cell function 
      compared to being lean. The overweight/obese T2DM group also had worse metabolic 
      profile manifested by higher FPG, HbA1c, SGPT and blood pressures compared to the 
      lean T2DM group.
CI  - (c) 2019 Journal of the ASEAN Federation of Endocrine Societies.
FAU - Bautista, Francesca Paula
AU  - Bautista FP
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, St. 
      Luke's Medical Center, Quezon City, Philippines.
FAU - Jasul, Gabriel Jr
AU  - Jasul G Jr
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, St. 
      Luke's Medical Center, Quezon City, Philippines.
FAU - Dampil, Oliver Allan
AU  - Dampil OA
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, St. 
      Luke's Medical Center, Quezon City, Philippines.
LA  - eng
PT  - Journal Article
DEP - 20191110
PL  - Philippines
TA  - J ASEAN Fed Endocr Soc
JT  - Journal of the ASEAN Federation of Endocrine Societies
JID - 8608483
PMC - PMC7784152
OTO - NOTNLM
OT  - beta-cell function
OT  - insulin resistance
OT  - lean
OT  - obese
OT  - overweight
OT  - type 2 diabetes mellitus
COIS- The authors declared no conflict of interest.
EDAT- 2019/01/01 00:00
MHDA- 2019/01/01 00:01
PMCR- 2019/01/01
CRDT- 2021/01/14 05:46
PHST- 2019/06/20 00:00 [received]
PHST- 2019/08/19 00:00 [accepted]
PHST- 2021/01/14 05:46 [entrez]
PHST- 2019/01/01 00:00 [pubmed]
PHST- 2019/01/01 00:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - JAFES-34-2-164 [pii]
AID - 10.15605/jafes.034.02.07 [doi]
PST - ppublish
SO  - J ASEAN Fed Endocr Soc. 2019;34(2):164-170. doi: 10.15605/jafes.034.02.07. Epub 
      2019 Nov 10.