PMID- 33442340 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210115 IS - 1660-3796 (Print) IS - 1660-3818 (Electronic) IS - 1660-3796 (Linking) VI - 47 IP - 6 DP - 2020 Dec TI - Recent Advances in Good Manufacturing Practice-Grade Generation of Dendritic Cells. PG - 454-463 LID - 10.1159/000512451 [doi] AB - Dendritic cells (DCs) are pivotal regulators of immune responses, specialized in antigen presentation and bridging the gap between the innate and adaptive immune system. Due to these key features, DCs have become a pillar of the continuously growing field of cellular therapies. Here we review recent advances in good manufacturing practice strategies and their individual specificities in relation to DC production for clinical applications. These take into account both small-scale experimental approaches as well as automated systems for patient care. CI - Copyright (c) 2020 by S. Karger AG, Basel. FAU - Cunningham, Sarah AU - Cunningham S AD - Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Erlangen, Germany. FAU - Hackstein, Holger AU - Hackstein H AD - Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Erlangen, Germany. LA - eng PT - Journal Article PT - Review DEP - 20201028 PL - Switzerland TA - Transfus Med Hemother JT - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie JID - 101176417 PMC - PMC7768120 OTO - NOTNLM OT - Dendritic cells OT - Good manufacturing practice OT - Monocytes COIS- The authors have no conflicts of interest to declare. EDAT- 2021/01/15 06:00 MHDA- 2021/01/15 06:01 PMCR- 2020/10/28 CRDT- 2021/01/14 05:46 PHST- 2020/04/22 00:00 [received] PHST- 2020/10/11 00:00 [accepted] PHST- 2021/01/14 05:46 [entrez] PHST- 2021/01/15 06:00 [pubmed] PHST- 2021/01/15 06:01 [medline] PHST- 2020/10/28 00:00 [pmc-release] AID - tmh-0047-0454 [pii] AID - 10.1159/000512451 [doi] PST - ppublish SO - Transfus Med Hemother. 2020 Dec;47(6):454-463. doi: 10.1159/000512451. Epub 2020 Oct 28.