PMID- 33442621 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220419 IS - 2514-2119 (Electronic) IS - 2514-2119 (Linking) VI - 4 IP - 6 DP - 2020 Dec TI - One-shot transcatheter double valve replacement: six-month follow-up-a case report. PG - 1-4 LID - 10.1093/ehjcr/ytaa335 [doi] AB - BACKGROUND: Transcatheter aortic valve replacement (TAVR) in combination with a valve-in-valve (V-i-V) transcatheter mitral valve replacement (TMVR) is a rare procedure in comparison to surgical therapy especially in young patients. We report on a young patient at high surgical risk, receiving a double valve implantation with two S3 transcatheter heart valves. CASE SUMMARY: A 59-year-old female patient with two previous mitral valve replacements due to endocarditis and re-endocarditis experienced a new onset of severe mitral valve stenosis in combination with progredient aortic stenosis. She was admitted to the hospital with severe dyspnoea and intermittent non-invasive ventilation [New York Heart Association (NYHA) III-IV]. An interventional transapical transcatheter double valve implantation was planned and carried out due to cardiac decompensation and high comorbidity preoperatively (STS score of 6.92). At 6-month follow-up, the patient presented herself in an improved condition with reduced symptoms (NYHA I-II), a good functional status of both valves and an advanced right and left ventricular function in the echocardiogram. DISCUSSION: Even in younger patients at high risk, a combined native TAVR and V-i-V TMVR procedure can be performed. In this case, a transcatheter SAPIEN 3 valve was transapically implanted with good clinical mid-term outcome at 6 months. CI - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Lutter, Georg AU - Lutter G AD - Department of Experimental Cardiac Surgery and Heart Valve Replacement, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, House C 210, D-24105 Kiel, Germany. AD - Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, House C 210, D-24105 Kiel, Germany. FAU - Salem, Mohamed AU - Salem M AD - Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, House C 210, D-24105 Kiel, Germany. FAU - Frank, Derk AU - Frank D AD - Department of Cardiology and Angiology, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, House C 210, D-24105 Kiel, Germany. FAU - Puehler, Thomas AU - Puehler T AUID- ORCID: 0000-0002-4990-1892 AD - Department of Experimental Cardiac Surgery and Heart Valve Replacement, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, House C 210, D-24105 Kiel, Germany. AD - Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 3, House C 210, D-24105 Kiel, Germany. LA - eng PT - Journal Article DEP - 20201114 PL - England TA - Eur Heart J Case Rep JT - European heart journal. Case reports JID - 101730741 PMC - PMC7793151 OTO - NOTNLM OT - Minimally invasive valve surgery OT - Case report OT - TAVR OT - TMVR OT - Transcatheter aortic valve implantation OT - Transcatheter mitral valve implantation EDAT- 2021/01/15 06:00 MHDA- 2021/01/15 06:01 PMCR- 2020/11/14 CRDT- 2021/01/14 05:48 PHST- 2020/02/25 00:00 [received] PHST- 2020/05/04 00:00 [revised] PHST- 2020/09/02 00:00 [accepted] PHST- 2021/01/14 05:48 [entrez] PHST- 2021/01/15 06:00 [pubmed] PHST- 2021/01/15 06:01 [medline] PHST- 2020/11/14 00:00 [pmc-release] AID - ytaa335 [pii] AID - 10.1093/ehjcr/ytaa335 [doi] PST - epublish SO - Eur Heart J Case Rep. 2020 Nov 14;4(6):1-4. doi: 10.1093/ehjcr/ytaa335. eCollection 2020 Dec.