PMID- 33443056
OWN - NLM
STAT- MEDLINE
DCOM- 20220201
LR  - 20220201
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 69
IP  - 3
DP  - 2021 Mar
TI  - Graft survival effect of HLA-A allele matching parathyroid allotransplantation.
PG  - 785-788
LID - 10.1136/jim-2020-001648 [doi]
AB  - Permanent hypoparathyroidism is an endocrine disease that is mostly associated 
      with the disruption of the parathyroid glands during surgery. Allotransplantation 
      is the most promising approach for treatment particularly for its cost-effective 
      and exact curative potential. Herein our aim was to evaluate human leukocyte 
      antigen (HLA)-A allele matching effect on clinical improvement and graft survival 
      after parathyroid transplantation. We performed parathyroid transplantation 
      between ABO/Rh compatible recipient and an unrelated donor who has chronic kidney 
      disease. Preoperative immunological tests include panel reactive antibody, T-flow 
      cytometry crossmatch, B-flow cytometry crossmatch, autoflow cytometry crossmatch, 
      and complement-dependent cytotoxicity crossmatch tests were performed. After 
      histopathological evaluation, half of the resected parathyroid gland cells were 
      isolated and transplanted to the omentum surface by laparoscopy. The 
      transplantation outcome was followed up throughout 382 days. The recipient 
      discharged 2 days after transplantation without any complication. During 
      follow-up, calcium and vitamin D supplementation reduced to a one-third dose; 
      even the intact PTH levels remained low. However, clinical improvement was 
      observed by serum calcium levels. The recipient still continues with low-dose 
      supplementation after 382 days of post-transplantation. Parathyroid cell 
      transplantation to the omental tissue is the most promising option even with only 
      one allele matching for patients with using lifelong high-dose supplementation. 
      Clinical improvements and long-term effect of HLA-A allele matching should be 
      evaluated with more studies and in larger cohorts as well.
CI  - (c) American Federation for Medical Research 2021. No commercial re-use. See rights 
      and permissions. Published by BMJ.
FAU - Goncu, Beyza
AU  - Goncu B
AUID- ORCID: 0000-0001-6026-8218
AD  - Experimental Research Center, Bezmialem Vakif University, Istanbul, Turkey 
      bsgoncu@gmail.com.
AD  - Parathyroid Transplantation Laboratory, Bezmialem Vakif University, Istanbul, 
      Turkey.
FAU - Salepcioglu Kaya, Harika
AU  - Salepcioglu Kaya H
AD  - Faculty of Medicine, Department of General Surgery, Bezmialem Vakif University, 
      Istanbul, Turkey.
FAU - Yucesan, Emrah
AU  - Yucesan E
AD  - Faculty of Medicine, Department of Medical Biology, Bezmialem Vakif University, 
      Istanbul, Turkey.
FAU - Ersoy, Yeliz Emine
AU  - Ersoy YE
AD  - Faculty of Medicine, Department of General Surgery, Bezmialem Vakif University, 
      Istanbul, Turkey.
AD  - Parathyroid Transplantation Laboratory, Bezmialem Vakif University, Istanbul, 
      Turkey.
FAU - Akcakaya, Adem
AU  - Akcakaya A
AD  - Faculty of Medicine, Department of General Surgery, Bezmialem Vakif University, 
      Istanbul, Turkey.
AD  - Organ Transplantation Unit, Bezmialem Vakif University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201222
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (HLA-A Antigens)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Alleles
MH  - Calcium/blood
MH  - *Graft Survival
MH  - *HLA-A Antigens
MH  - Humans
MH  - *Parathyroid Glands/immunology/surgery
MH  - Transplantation, Homologous
OTO - NOTNLM
OT  - endocrinology
OT  - immunologic tests
OT  - parathyroid hormone
OT  - transplants
COIS- Competing interests: None declared.
EDAT- 2021/01/15 06:00
MHDA- 2022/02/02 06:00
CRDT- 2021/01/14 08:46
PHST- 2020/12/09 00:00 [accepted]
PHST- 2021/01/15 06:00 [pubmed]
PHST- 2022/02/02 06:00 [medline]
PHST- 2021/01/14 08:46 [entrez]
AID - jim-2020-001648 [pii]
AID - 10.1136/jim-2020-001648 [doi]
PST - ppublish
SO  - J Investig Med. 2021 Mar;69(3):785-788. doi: 10.1136/jim-2020-001648. Epub 2020 
      Dec 22.